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Neonate product selection
- 1. Try to give CPD or CPDA
- 2. Using AS-1 is institution specific
- a. Some studies suggest AS-1 may be harmful.
- 3. If transfusing non-O, the RBC must be compatible with neonate and Mom or must test infant for anti-A and anti-B
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Irradiated blood products are used for:
- Immunocompromised
- directed donations from family member
- HLA matched components
Goal is to prevent GVHD
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Cold Antibodies
In cold climates, you find igloos (Ii) & Penquins (P).
Penquin is carrying a bag of M&Ms (MN)
Veronic Lewis (Lewis) is dressed up as an Eskimo waving Hi (H).
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What may cause an autocontrol to be positive and DAT is negative?
May be antibodies to enhancement medium or an autoantibody that reacts only in the enhancement medium.
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What antibodies are not developed at birth?
Lewis and I
* There are others, but for this case, only mentioning Lewis and I.
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Enzymes treated cells destroy and enhance which major antibodies?
MN, Duffy, & Xga - Antgiens are destroyed or reduced
Lewis, Rh, & Kidd - Antigens enhanced.
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Which antibodies may be ruled out on heterozygous cells
- If with anti-D, can you rule out C & E with a heterozygous cell. Almost all D negs are rr.
- There is a low chance of getting r' or r" cells.
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Cannot always rule out...
Rare Rh: f, V, Cw
Low incidence: Jsa, Kpa, Lua
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