GI drugs

  1. Treat C. difficile
    Metronidazole or vancomycin PO
  2. Risks of short term PPI use
    Increased risk of pneumonia
  3. risks for long term use of PPIs
    • Fractures,
    • hypomagnesia,
    • c. diff
  4. Drugs that interact with PPIs
    Clopidogrel, diazepam
  5. Duration of PPI treatment for upper GI bleed
    4-8 weeks
  6. antacids should not be given with which antibiotics
    Tetracyclines and fluoroquinolones
  7. which antacids should be avoided in renal insufficiency
    Aluminum and magnesium (and combination)
  8. sucralfate
    • binds to ulcer site
    • may cause constipation
    • administer 30 minutes apart if giving antacid also
  9. side effects of H2 blockers
    Headache, dizziness, CNS disturbances, rash, pruritis
  10. 2 examples of H2 blockers
    • Famotidine: Pepcid: 10-40 mg
    • ranitidine: Zantac: 75-300 mg
  11. medication to prevent nsaid ulcers
    misoprostol: prostaglandin analogue TERATOGENIC
  12. metoclopramide / Reglan
    • Increases motility,
    • suppresses nausea/vomiting.
    • adverse effects: tardive dyskinesia, extrapyramidal symptoms, diarrhea, sedation
  13. adverse effects of erythromycin as a pro kinetic
    Nausea/vomiting, QT prolongation, change in gut biome
  14. preferred steroid for inflammatory bowel flare ups
  15. adverse effects of remicade/infliximab
    Hepatitis, vasculitis, bone marrow suppression, infection, heart failure exacerbation, fever, rash, pruritis
  16. Adverse effects of methotrexate
    Bone marrow suppression, liver toxicity, pulmonary toxicity
  17. monoclonal antibody anti diarrheal
    humira, remicade
  18. antidiarrheal
    loperamide / Imodium
  19. antispasmodic
    Dicyclomine / bentyl
  20. Bile acid binder
  21. contraindications for laxative use
    Undiagnosed abdominal pain, cramps, obstruction, diverticulitis, ulcerative colitis
  22. good laxative for IBS and diverticulitis
    Bulk forming: psyllium
  23. senna
    stimulant laxative, often used for opioid users. Can discolor urine.
  24. laxative safe for pregnancy
  25. surfactant laxative
    Colace. Soften stools
  26. saline osmotic
    softens stool, helps peristalsis
  27. adverse reactions of saline osmotics
    water loss, toxic Mg or K levels in pts with renal insufficiency
  28. contraindications to saline osmotics
    Heart failure, cirrhosis, renal dysfunction
  29. Drugs that cause diarrhea
    Levothyroxine, NSAIDs, sorbitol, digoxin, colchicine
  30. least abuseable opioid anti diarrheal
    Imodium ( doesn’t cross BBB)
  31. pesto bismol mechanism of action and generic name
    binds toxins. Coats lining. Bismuth subsalicylate
  32. treat mild to moderate community acquired peritonitis
    Cefoxitin, moxifloxacin
  33. treat high risk, severe, or hospital acquired peritonitis
    Zosyn,  or cefipime + metronidazole
  34. antibiotics for prophylaxis in variceal bleed patients
    Ceftriaxone, Bactrim, or a fluoroquinolone
  35. best antidiarrheal for HIV associated diarrhea
  36. Prostaglandin analogue to prevent NSAID ulcer
    • Misoprostol / Cytotec
    • contraindicated in women of childbearing age
  37. patient instructions and warnings when prescribing PPI
    Supplement with calcium and vitamin d to reduce fracture risk, avoid those with influenza like illnesses
  38. What antacids are appropriate for patients with renal failure?
    Calcium / Tums
Card Set
GI drugs
Therapeutic regimens for GI diagnoses