Dyslipidemia

  1. Pathophysiology of dyslipidemia
    • Low Density Lipoproteins (LDL) begin to bind to damaged glycoproteins in the glycocalyx.
    • Loss of SOD from the glycocalyx and increase in SuperOxide = oxidised LDL (oxLDL).
    • Oxidised LDL drives RAGERAGE increases NF-KBNF-KB increases synthesis of inflammatory proteins and chemoattractant proteins which attract Monocytes
    • Monocytes penetrate endothelial cell junctions, entering the tunica intima and creating foam cells
    • Plaques, composed of SMC’s, foam cells, oxidised cholesterol and collagen/fibrin matrices start to migrate into Intima layer and can be displaced by shear pressure leading to thrombosis and potential ischaemia.
  2. Nutritional Management of Dyslipidemia
    • Mediterranean Diet -
    • Moderate consumption of alcohol (mostly from wine)
    • low consumption of meat and meat products to limit saturated fat
    • high consumption of vegetables, fruits, nuts, legumes, fish, and olive oil.
  3. Supplements for dyslipidemia
    • Red Yeast Rice
    • Plant Sterols
    • Niacin
    • Omega 3 FAs
    • Sesame
    • Flaxseeds
    • Garlic
    • NAC
    • Resveratrol
    • Tocotrienols
    • MUFAs
    • Green Tea
    • Probiotics
Author
A5
ID
340726
Card Set
Dyslipidemia
Description
Dyslipidemia
Updated