Pathophysiology of dyslipidemia
- Low Density Lipoproteins (LDL) begin to bind to damaged glycoproteins in the glycocalyx.
- Loss of SOD from the glycocalyx and increase in SuperOxide = oxidised LDL (oxLDL).
- Oxidised LDL drives RAGERAGE increases NF-KBNF-KB increases synthesis of inflammatory proteins and chemoattractant proteins which attract Monocytes
- Monocytes penetrate endothelial cell junctions, entering the tunica intima and creating foam cells
- Plaques, composed of SMC’s, foam cells, oxidised cholesterol and collagen/fibrin matrices start to migrate into Intima layer and can be displaced by shear pressure leading to thrombosis and potential ischaemia.
Nutritional Management of Dyslipidemia
- Mediterranean Diet -
- Moderate consumption of alcohol (mostly from wine)
- low consumption of meat and meat products to limit saturated fat
- high consumption of vegetables, fruits, nuts, legumes, fish, and olive oil.
Supplements for dyslipidemia
- Red Yeast Rice
- Plant Sterols
- Omega 3 FAs
- Green Tea