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HCTZ
- hydrouiril
- Thiazide--> increases NA and CL excreted from distal tubule
- Dose: 12.5- 100mg qd
- DI: digoxin, corticosteroids, NSAIDs,
- SE: photosensitivity, sexual dysfunction, sulfa
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Furosemide
- Lasix
- Loop--> blocks absorption of sodium and cl in proximal tubule
- DOSE: 20-80mg qd
- DI: corticosteroids, aminoglycosides, NSAIDS,
- SE: hypouricemia, hypokalemia, sulfa
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Sprinolactone
- aldactone
- aldosterone antagonist: competes with aldosterone at the na/k exchange site of the distal tubule --> inc K retention and increases na excretion
- dose: 25-200 mg in divided doses
- DI: ACE , NSAIDs, K
- SE: hyperkalemia, gynecomastia, ha, nvd
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Triamterene/ hctz
- dyazide/maxide
- Potassium sparring + thiazide
- dose: 37.5-75/ 25-50 mg qd
- DI: ace, NSAIDs,
- SE: hyperkalemia, gynecomastia, ha, nvd, digoxen, corticosteroids, photosensitivty, sexual dysfunction, sulfa
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