-
Atorvastatin
- Lipitor
- Dose:10 – 80 mg po once daily
- DI:fibrates, niacin, 3a4,
- SE:dyspepsia, diarrhea, myopathy, rhabdomyloysis
-
Simvastatin
- Zocor
- MOA: hmg coa inhibitor
- Dose: 5 – 80 mg po
- once daily
- DI: Fibrates, niacin, 3a4
- SE: dyspepsia, diarrhea, myopathy, rhabdomyloysis
-
Lovastatin
- Mevacor
- MOA: HMG-COA inhibitor
- dose: 10-80 mg po in 1-2 divided doses
- DI: fibrates, niacin, 3a4
- DE: dyspepesia, diarrhea, myopathy, rhabdomyaloysis
-
Rosuvastatin
- Crestor
- MOA: HMG coa inhibitor
- dose: 5-40 mg po qd
- DI: fibrates, niacin, warfarin, macrolides
- SE: dyspepesia, diarrhea, myopathy, rhabdomyaloysis
-
Pravastatin
- Pravachol
- MOA: HMG coa reductase inhib
- dose: 10-80 mg po qd
- DI: fibrates, niacin, warfarin, macrolides
- se: dyspepsia, diarrehea, myopathy, rhabdomyoylsis
-
Ezeimibe
- Zetia
- MOA: cholesterol absorption inhibitor
- dose: 10mg po qd
- Di: bile acid resins (cholestyramine colestipol) fibrates
- SE: GI upset, diarrhea, fatigue
-
-
Fenofibrate
- Tricor
- MOA:fibrate:activation of PPARY receptor that activate lipase and decrease apo protein c III leading to clearance of TF
- DOSE:48-145 mg po qd
- DIstatins, niacin, warfarin, rosiglitazone, glyburide
- SE:dyspepsia, myopathy, gallstones, rash, elevated liver enzymes
-
Gemfibrozil
- Lopid
- MOA: fibrate: activate PPARY receptor that activate lipase and dec apo-protein c III leading to clearance of tg
- DOSE: 600 mg po bid
- DI: statins, niacin, warfarin, rosiglitzone, glyburide
- SE: dyspepsia, myopathy, gallstones, rash, elevaed liver enzymes
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