Patho Test 1 (7)

Harmful effects of hypersensitivity to environmental (exogenous) antigens

Disturbances in the immunologic tolerance of self-antigens

Immune reaction to tissues of another individual

IgE mediated

• •Tissue-specific reactions
• -Cell destruction by antibody and complement
• -Cell destruction through phagocytosis

• Type III
• •Immune complex mediated
• -antibodies bind to soluble antigen that was released into the body or fluids, and then the complex is deposited into tissue

• •Cell mediated
• -mediated by T lymphocytes; DO NOT involve antibody

• •Genetic /Hereditary in origin
• •Clinical Manifestations
• 1. urticaria
• 2. rhinitis
• 3. mild breathing problems
• 4. pruritis
• 5. edema

•Environmental antigens that cause atypical immunologic responses in genetically predisposed individuals •Pollens, molds and fungi, foods, animals, etc.•Symptoms range from annoying to life threatenin

• •Most rapid and severe immediate Type 1 hypersensitivity reaction
• -Occurs within minutes of reexposure to antigen
• -Systemic or cutaneous
• -Most severe reactions can lead to shock and death
• -Common causes are beestings or eating peanuts, shellfish, or eggs