Pharmacokinetics

Fraction of administered dose that reaches systemic circulation

• F = AUC(route)/AUC (IV)
• [no units]

Volume of distribution describes the drug's ability to distribute from blood throughout the body

• Vd(apparent) = amount of drug in body/ (Cp)
• [L/kg]

Concentration of drug in plasma

Amount of drug removed from body per unit time

• Amount of drug removed from body/time
• [mg/hr]

Clearance is the amount of plasma from which the "total body" can remove the drug per unit time

• Cl = rate of elimination / (Cp)
• [L/hr]

Half life is the time it takes form plasma concentration of drug to reach 1/2 it's original concentration at time zero

• t1/2 = 0.693 * Vd / Cl
• [time units]

LD = Vd* Cp / F

MD= Cl* Cp / F

~4-5

• Ethanol
• Aspirin
• Phenytoin

• Phenytoin CYP2C8-10
• Rifampin CYP2C8-10
• St. John's Wort CYP3A