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Pharmacokinetics
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F - Bioavailability
Fraction of administered dose that reaches systemic circulation
F - Bioavailability formula
F = AUC(route)/AUC (IV)
[no units]
Vd
Volume of distribution describes the drug's ability to distribute from blood throughout the body
Vd formula
Vd(apparent) = amount of drug in body/ (Cp)
[L/kg]
Cp
Concentration of drug in plasma
Elimination
Amount of drug removed from body per unit time
Elimination formula
Amount of drug removed from body/time
[mg/hr]
Cl
Clearance is the amount of plasma from which the "total body" can remove the drug per unit time
Cl formula
Cl = rate of elimination / (Cp)
[L/hr]
t1/2
Half life is the time it takes form plasma concentration of drug to reach 1/2 it's original concentration at time zero
t1/2 formula
t1/2 = 0.693 * Vd / Cl
[time units]
LD - loading dose
LD = Vd* Cp / F
MD - maintenance dose
MD= Cl* Cp / F
How many 1/2 lives to steady state (1st order)
~4-5
Drugs with zero order kinetics
Ethanol
Aspirin
Phenytoin
CYP450 Inducers
Phenytoin CYP2C8-10
Rifampin CYP2C8-10
St. John's Wort CYP3A
Author
ketch22
ID
337554
Card Set
Pharmacokinetics
Description
Pharmacokinetics
Updated
2018-01-27T14:15:34Z
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