Antifungals

  1. This formulation of amphotericin B is dosed at 0.1-1.5 mg/kg/day
    Conventional amphotericin B
  2. This formulation of amphotericin B is dosed at 3-6 mg/kg/day
    Liposomal amphotericin B (AmBisome)
  3. Conventional amphotericin B requires premedication to reduce infusion-related reactions which are fever, chills, headache, malaise, rigors, nephrotoxicity and reduction of these two electrolytes
    K and Mg
  4. Hypokalemia may increase the risk of this drug toxicity
    Digoxin
  5. This azole agent is the only one that requires renal dose adjustment
    Fluconazole (Diflucan)
  6. This azole is considered a drug of choice for Aspergillus 
    Voriconazole (Vfend)
  7. All brands are topical: Nizoral, Extina, Xolegel
    Ketoconazole
  8. Diflucan
    Fluconazole
  9. Sporanox, Onmel
    Itraconazole
  10. Capsule and solution of this agent are NOT interchangeable. 
    Capsule/tablet: take with food
    Solution: take on empty stomach
    Itraconazole (Sporanox, Onmel)
  11. Due to risk of hepatotoxicity, use of this agent orally is only considered when other antifungal therapy is unavailable or not tolerated
    Ketoconazole
  12. Use of this agent is C/I for treatment of onychomycosis in patients with ventricular dysfunction or a history of HF
    Itraconazole (Sporanox, Onmel)
  13. Side Effects: elevated LFT, QT prolongation, hypoK, hyperTG, HTN, headache, N/V, abdominal pain, rash/pruritus, edema, dizziness, hair loss (or hair growth)
    Azoles
  14. This azole agent carries warnings for:
    Liver damage
    Visual disturbances
    Embryofetal toxicity
    QT prolongation
    Phototoxicity
    CNS toxicity (hallucination)
    Voriconazole (Vfend)
  15. "Caution driving at night, avoid direct sunlight, hold tube feeding, do not refrigerate oral suspension" are counseling points for this azole
    Voriconazole (Vfend)
  16. This azole is C/I with atorvastatin, lovastatin, simvastatin
    Posaconazole (Noxafil)
  17. Take this azole with full meal
    Posaconazole (Noxafil)
  18. All the azole antifungals can cause low level of K and Mg while causing elevation of this
    LFT
  19. Cresemba
    Isavuconazonium sulfate
  20. Due to possible particulates with Cresemba, this is required during administration
    A filter
  21. All azoles can increase INR. Greatest risk with these three azoles
    • Fluconazole
    • Ketoconazole
    • Voriconazole
  22. Candidas
    Caspofungin
  23. Mycamine
    Micafungin
  24. Eraxis
    Anidulafungin
  25. Echinocandins are caspofungin, micafungin, and anidulafungin.  All are IV, given once daily and do not require renal dose adjustment.  Side effects include hypotension, elevated LFTs and low level of these two electrolytes
    K and Mg
  26. This antifungal agent is C/I in pregnancy. Side effect includes elevated LFT, dizziness, photosensitivity. It has possible cross reaction with PCN allergy. Advise to take with a fatty meal to increase absorption or with food/milk to lower GI upset
    Griseofulvin (Grifulvin V, Gris-PEG)
Author
ximuoi2001
ID
337328
Card Set
Antifungals
Description
Antifungal agents
Updated