Antifungals

This formulation of amphotericin B is dosed at 0.1-1.5 mg/kg/day

This formulation of amphotericin B is dosed at 3-6 mg/kg/day

Conventional amphotericin B requires premedication to reduce infusion-related reactions which are fever, chills, headache, malaise, rigors, nephrotoxicity and reduction of these two electrolytes

Hypokalemia may increase the risk of this drug toxicity

This azole agent is the only one that requires renal dose adjustment

This azole is considered a drug of choice for Aspergillus 

All brands are topical: Nizoral, Extina, Xolegel

Diflucan

Sporanox, Onmel

Capsule and solution of this agent are NOT interchangeable. 
Capsule/tablet: take with food
Solution: take on empty stomach

Due to risk of hepatotoxicity, use of this agent orally is only considered when other antifungal therapy is unavailable or not tolerated

Use of this agent is C/I for treatment of onychomycosis in patients with ventricular dysfunction or a history of HF

Side Effects: elevated LFT, QT prolongation, hypoK, hyperTG, HTN, headache, N/V, abdominal pain, rash/pruritus, edema, dizziness, hair loss (or hair growth)

This azole agent carries warnings for:
Liver damage
Visual disturbances
Embryofetal toxicity
QT prolongation
Phototoxicity
CNS toxicity (hallucination)

"Caution driving at night, avoid direct sunlight, hold tube feeding, do not refrigerate oral suspension" are counseling points for this azole

This azole is C/I with atorvastatin, lovastatin, simvastatin

Take this azole with full meal

All the azole antifungals can cause low level of K and Mg while causing elevation of this

Cresemba

Due to possible particulates with Cresemba, this is required during administration

All azoles can increase INR. Greatest risk with these three azoles

Candidas

Mycamine

Eraxis

Echinocandins are caspofungin, micafungin, and anidulafungin.  All are IV, given once daily and do not require renal dose adjustment.  Side effects include hypotension, elevated LFTs and low level of these two electrolytes

This antifungal agent is C/I in pregnancy. Side effect includes elevated LFT, dizziness, photosensitivity. It has possible cross reaction with PCN allergy. Advise to take with a fatty meal to increase absorption or with food/milk to lower GI upset