Final-FA and krebs

glucose-(glycolysis)-->2 pyruvate-(PDH)-> Acetate---> Krebs Cycle

• Pyruvate--->acetyl-CoA
• using: CoASH and NAD

• TPP-carbanion on CSN ring
• Lipoic acid-the 2 sulfurs remove H to add CoASH
• FAD, NAD- remove H from Lipoic acid and remove H from FAD

Acetyl-CoA + Oxaloacetate, Citrate, Isocitrate, Oxalosuccinate, α-ketoglutarate, Succinyl-CoA, Succinate, Fumarate, L-malate, Oxaloacetate

• isocitrate-oxalosuccinate (NAD)
• a KG-Succinyl CoA (Nad and CoA)
• succinyl CoA- Succinate (GDP)
• Succinate-Fumarate (FAD)
• L-malate-oxaloacetate (NAD)

• isocitrate-oxaloasuccinate (NADH)
• oxalosuccinate-aKG (CO2)
• aKG-Succinyl-coa (NADH and CO2)
• succinyl-coa- succinate (GTP)
• succinate-fumarate (FADH2)
• L-Malate-oxaloacetate (NADH)

• bile emulsifies fat to micelles
• lipases convery triaclyglycerides into FA
• Chylomicron carry new formed TG to tissues
• liver, adipose stores the lipids

• activation w/ CoA- outer membrane
• transport into the matrix (carnitine)
• oxidation to acetyl-CoA (4 steps)

Lipid+ATP+CoASH--> Lipid w/ S-CoA

carnitine-removes CoA and moves all the way to the matrix and CoA is added back on

• 1. form double bond between beta and alpha carbon (FAD)
• 2. hydrolize to form alcohol on beta carbon
• 3. oxidize alcohol (NAD)
• 4. Add CoA-SH to form acetyl coa and lipid chain w/ S-CoA