Rotation Quiz 3-5

  1. Erroneous ammonia levels can be eliminated by all of the following excpet:

    D. storing the specimen protected from light until the analysis is done
  2. A blood creatinine value of 5.0 mg/dL is most likely to be found with which of the following blood values?

    C. urea nitrogen: 80 mg/dL
  3. A serum sample was assayed for bilirubin at 10 AM and the result was 12 mg/dL.  The same sample was retested at 3 PM and the result is not 8 mg/dL.  The most likely explanation for this discrepancy is:

    A. the sample was exposed to light
  4. Which of the following enzymes are used in the diagnosis of acute pancreatitis?

    A. amylase and lipase
  5. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are both elevated in which of the following diseases?

    A. viral hepatitis
  6. The enzyme present in almost all tissue may be separated by electrophoresis into 5 components is:

    C. lactate dehydrogenase
  7. Which analyte would be decreased in liver disease?

    D. albumin
  8. In which of the following conditions would a normal level of creatine kinase be found?

    C. hepatits
  9. Given the following results:
    alk phos: slight increase
    AST: slight increase
    ALT: slight increase
    GGT: slight increase

    This is most consistent with:

    D. chronic hepatitis
  10. Why is it possible to measure total bilirubin in a neonatal serum sample using direct spectrophotometry, but this technique cannot be used to measure total bilirubin in an adult serum sample?

    C.  adult samples contain carotene and other pigments that increase the absorbance at the wavelength where bilirubin is measured
  11. The most widely used methods for bilirubin measurement are those based on the:
    a. jaffe reaction
    b. schales and schales method
    8-hydroxyquinolone reaction
    d. jendrassik-Grof method
    d. jendrassik-Grof method
  12. How would hemolysis affect a plasma ammonia level?

    A. increase
  13. a 65 yo patient is being monitored for kidney disease as a precautionary measure because the patient has coronary heart disease. Screening renal tests were recently assay.  The patient's plasma BUN and creatinine and urine protein were all elevated.  These showed that the patient has likely developed kidney disease.  WHich of the following would be the most probable result of an estimated glomelular filtration rate (eGFR) is the patient does have renal disease?

    A. decreased eGFR
  14. Kernicterus is an abnormal accumulation of bilirubin in:

    C. brain tissue
  15. AN electrophoretci separation of lactate dehydrogenase isoenzymes that demonstrates an elevation in LD-1 and LD-2 is a "flipped" patter is consistent with:

    B. myocardial infarction
  16. An aspartate aminotransferase (AST) test is analyzed on a patient sample and the result is below the analytical measurement range (AMR), which for the instrument in this scenarios is 4.0-9.0 U/L.  The laboratory director has stated that quantitating AST values that areless than 4 U/L are not clinically useful.  How should this patient's result be reported?
    a. <4.0 U/L
    b. 4.0 U/L
    unable to report; exceeds the measurement limit of the analyzer
    d. report the number the instrument provides
    a. <4.0 U/L
  17. The most heat labile fraction of alkaline phosphatase is obtained from:

    C. bone
  18. The most sensitive enzymatic indicator for liver damage from ethanol intake is:

    B. GGT
  19. Which of the following chemical determinations may be of help in establishing the presence of seminal fluid?

    A. acid phosphatase
  20. Transportation of 60-75% of the plasma cholesterol is performed by:

    D. low density lipoproteins
  21. A critically ill patient has become comatose.  The physician believes the come is due to hepatic failure. The assay most helpful in this diagnosis is:

    A. ammonia
  22. Which of these staatements is true regarding therapeutic drug monitoring (TDM)?

    D. TDM can be used to detect an interaction between two or more drugs that a patient is taking at the same time
  23. A drug has a half like of 6 hours.  If a dose is given every 6 hours, a stead-state drug level would usually be achieved in:

    A. 24-42 hours
  24. The presence of which of the followin isoenzymes indicates acute myocardial damage?

    D. CKMB
  25. Which of the following would have the greatest impact on a gentamicin test result?

    A. time of collection in relation to drug dosing
  26. An anti-epileptic (or anticonvulsant) used to control seizure disorders is:

    C. phenytoin
  27. A cardiac glycoside that is used in the treatment of congenital heart failure and arrythmias by increasing the force and velocity of myocardial contraction is:

    C. digoxin
  28. A sample received from the cardiac unit of you facility for a STAT digoxin level.  Your instrument reports the result as 3.0 ng/mL and flags it as a critical value.  After repeating the test and confirming the result, what should be your next action?

    C. phone the cardiac unit and give the result to the clinical person responsible for the patient's care
  29. A drug must be in which of the following states to have therapeutic effect?

    B. free, not bound to protein
  30. An increase in which fo the following cardiac biomarkers is most often associated with congestive heart failure?

    B. BNP
  31. Which of the following factors is not relevant to therapeutic drug monitoring of the aminoglycoside, antibiotics and vancomycin?

    C. intestinal absorption
  32. The drug procanimide is prescribed to treat cardiac arrythmia.  Wht biologically active liver metabolite of procainamide is often measured simultaneously?

    C. N-acetyl procainimide (NAPA)
  33. A drug that relaxes the smooth muscles of the bronchial passages is

    B. theophylline
  34. Serum from a patient with metastatic carcinome of the prostate was separated from the clot and stored at RT. The following results were obtained;
    Ca 10.8 mg/dL (8.8-10.3 mg/dL)
    LD 120 U/L (50-150 U/L)
    Acid P'tase .1 U/L (0-5.5 U/L)
    The technician should repeat the:

    B. acid phosphatase with freshly drawn serum
  35. A chemiluminescent EIA:

    B. is quantitated by the amount of light produced by the reaction
Card Set
Rotation Quiz 3-5
Clin chem rotation quizzes