GI Drugs

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Balsalazide
- Mild to moderate ulcerative colitis and Crohn's disease
- Aminosalicylate
Prednisone
- Treatment of moderate to severe inflammatory bowel disease
- Should be used for less than two weeks
Budesonide
- Mild to moderate Crohn's disease
- Less effective than Prednisone but significantly less side effects
Azathioprine
- Induction and maintenance of remission of UC and Crohn's
- Monitor CBC and LFTs
Methotrexate
- Induce and maintain remission of IBD
- Inhibits dihydrofolate reductase
Infiximab
- Treatment of moderate to severe Crohn's with inadequate response to other
- Given bi-weekly or longer intervals
Natalizumab
- Moderate to severe Crohn's refractory to other therapies
- Progressive multifocal leukoencaphalopathy
Vedolizumab
- Moderate to severe Crohn's refractory to other therapies
- No PML reported
Linaclotide
- IBS with constipation
- Guanylate cyclase agonist
Lubiprostone
- IBS with constipation
- Chloride channel activator
Alosetron
- IBS with diarrhea
- Serotonin receptor antagonist
Loperamide
- Antidiarrheal
- Available OTC
Cholestyramine
- Antidiarrheal
- Bile salt binding resins
Octreotide
- Antidiarrheal
- Hypothyroidism with prolonged use
Psyllium
- Laxative
- Natural bulk-forming laxative
Docusate
- Laxative
- Stool softener
Magnesium Oxide
- Laxative
- Do not use in patients with renal insufficiency
Balanced Polyethylene glycol
- laxative
- Used for chronic cleansing before GI endoscopic procedures
Biscodyl
- Stimulant laxative
- Used for acute and chronic constipation
Methylnaltraxone
- Laxative
- Treatment of opioid induced constipation
Palonosetron
- Anti-emetic/Serotonin receptor antagonists
- Can be combined with dexamethasone or NK1 antagonist
Dexamethasone
- Anti-emetic/Corticosteroid
- Not used alone, used with serotonin antagonists or NK1 antagonist
Aprepitant
- Anti-emetic/NK1 antagonist
- Inhibits CYP3A4 metabolism
Prochlorperazine
- Anti-emetic/Dopamine 2 receptor antagonist
- EPS effects and Hypotension
Metoclopramide
- Anti-emetic
- Dopamine receptor antagonist
Diphenhydramine
- Anti-emetic/H1 antihistamine
- Treat motion sickness
Hyoscine (scopalamine)
- Anti-emetic/Muscarinic antagonist
- Used as a transdermal patch
Lorazepam

Anti-emetic/Benzo
Dronabinol
- Anti-emetic/Cannabinoid
- Can be used as an appetite stimulant
Sucralfate
- Used for upper GI bleed and stress-related bleeding
- May bind to and impair other drugs
Misoprostol
- Prostaglandin analog
- Prophylatic use for NSAID induced ulcers
Bismuth Subsalicylate
- Acute diarrhea and traveler's diarrhea
- Antimicrobial affects against H. pylori
Bismuth Subcitrate
- Used in combo with antibiotics and PPIs for H. pylori infection
- Rx
Clarithromycin

Treat H. pylori associated ulcers
Metronidazole

Treat H. pylori associated ulcers
Sodium Bicarbonate
- Antacid
- Causes belching and gastric distention
Calcium Carbonate
- Antacid
- Causes belching and gastric distention
Magnesium hydroxide and aluminium hydroxide
- Antacid
- Used together to cancel ADE
Cimetidine
- H2 receptor antagonists
- Used to treat heartburn and can be used prophylactically before meals
Omeprazole
- Proton pump inhibitor/prodrug
- Used for GERD. Use on empty stomach

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Pontoon

336020

Card Set

GI Drugs

Description

GI Drugs

Updated

2017-11-15T09:20:17Z

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