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GI Drugs

  1. Balsalazide
    • Mild to moderate ulcerative colitis and Crohn's disease
    • Aminosalicylate
  2. Prednisone
    • Treatment of moderate to severe inflammatory bowel disease
    • Should be used for less than two weeks
  3. Budesonide
    • Mild to moderate Crohn's disease
    • Less effective than Prednisone but significantly less side effects
  4. Azathioprine
    • Induction and maintenance of remission of UC and Crohn's
    • Monitor CBC and LFTs
  5. Methotrexate
    • Induce and maintain remission of IBD
    • Inhibits dihydrofolate reductase
  6. Infiximab
    • Treatment of moderate to severe Crohn's with inadequate response to other
    • Given bi-weekly or longer intervals
  7. Natalizumab
    • Moderate to severe Crohn's refractory to other therapies
    • Progressive multifocal leukoencaphalopathy
  8. Vedolizumab
    • Moderate to severe Crohn's refractory to other therapies
    • No PML reported
  9. Linaclotide
    • IBS with constipation
    • Guanylate cyclase agonist
  10. Lubiprostone
    • IBS with constipation
    • Chloride channel activator
  11. Alosetron
    • IBS with diarrhea
    • Serotonin receptor antagonist
  12. Loperamide
    • Antidiarrheal
    • Available OTC
  13. Cholestyramine
    • Antidiarrheal
    • Bile salt binding resins
  14. Octreotide
    • Antidiarrheal
    • Hypothyroidism with prolonged use
  15. Psyllium
    • Laxative
    • Natural bulk-forming laxative
  16. Docusate
    • Laxative
    • Stool softener
  17. Magnesium Oxide
    • Laxative
    • Do not use in patients with renal insufficiency
  18. Balanced Polyethylene glycol
    • laxative
    • Used for chronic cleansing before GI endoscopic procedures
  19. Biscodyl
    • Stimulant laxative
    • Used for acute and chronic constipation
  20. Methylnaltraxone
    • Laxative
    • Treatment of opioid induced constipation
  21. Palonosetron
    • Anti-emetic/Serotonin receptor antagonists
    • Can be combined with dexamethasone or NK1 antagonist
  22. Dexamethasone
    • Anti-emetic/Corticosteroid
    • Not used alone, used with serotonin antagonists or NK1 antagonist
  23. Aprepitant
    • Anti-emetic/NK1 antagonist
    • Inhibits CYP3A4 metabolism
  24. Prochlorperazine
    • Anti-emetic/Dopamine 2 receptor antagonist
    • EPS effects and Hypotension
  25. Metoclopramide
    • Anti-emetic
    • Dopamine receptor antagonist
  26. Diphenhydramine
    • Anti-emetic/H1 antihistamine
    • Treat motion sickness
  27. Hyoscine (scopalamine)
    • Anti-emetic/Muscarinic antagonist
    • Used as a transdermal patch
  28. Lorazepam
    Anti-emetic/Benzo
  29. Dronabinol
    • Anti-emetic/Cannabinoid
    • Can be used as an appetite stimulant
  30. Sucralfate
    • Used for upper GI bleed and stress-related bleeding
    • May bind to and impair other drugs
  31. Misoprostol
    • Prostaglandin analog
    • Prophylatic use for NSAID induced ulcers
  32. Bismuth Subsalicylate
    • Acute diarrhea and traveler's diarrhea
    • Antimicrobial affects against H. pylori
  33. Bismuth Subcitrate
    • Used in combo with antibiotics and PPIs for H. pylori infection
    • Rx
  34. Clarithromycin
    Treat H. pylori associated ulcers
  35. Metronidazole
    Treat H. pylori associated ulcers
  36. Sodium Bicarbonate
    • Antacid
    • Causes belching and gastric distention
  37. Calcium Carbonate
    • Antacid
    • Causes belching and gastric distention
  38. Magnesium hydroxide and aluminium hydroxide
    • Antacid
    • Used together to cancel ADE
  39. Cimetidine
    • H2 receptor antagonists
    • Used to treat heartburn and can be used prophylactically before meals
  40. Omeprazole
    • Proton pump inhibitor/prodrug
    • Used for GERD. Use on empty stomach
Author
Pontoon
ID
336020
Card Set
GI Drugs
Description
GI Drugs
Updated

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