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Main points to keep in mind about the difference in fluid outside or in the cell 4
- **K+ on outside is less than 5mM but in the cell its more than 100mM
- 1. outside is rich in Na and Cl but low in K+ vice versa inside cell
- 2. massive difference in Ca levels between in and out
- 3.more protein outside of cell
- 4. in cell is more acidic than outside
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in cell conc and out conc
K
Na
Ca
Cl
- I: K-120mM, Na-15,Ca-.001, Cl-20
- O: K-4.5, Na-145, Ca-1.2, Cl-102
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permeant solute
permeable to solute
- solute can pass through the layer
- the layer is allowing things to pass through
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fick equation determined the movement (flux) or diffusion of a solute across a barrier of a given surface area
- J is determined by:
- permeability of the solute across the barrier
- concentration gradient between 2 compartments separated by barrier (diff in concentration of solute in compartment)
- **C1-C2=0 movement is 0
- **if uncharged, solute determinant of the rate of movement is conc gradient
- **if charged the electro chem gradient is determined by diff in conc as well as electrical potential diff across mem
- permeability coefficient is determined by these 3:
- area for diffusion; the greater area higher net diffusion of solute (no individual molecule)
- solubility of the solute in the lipid phase of membrane
- thickness of the barrier (thin = better)
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