MCQ - Neurosurgery - Brain tumors II

  1. Types of Glioma?
    • • Astrocytoma (MC)Q
    • • OligodendrogliomaQ
    • • EpendymomaQ
  2. MC primary brain tumor in both children and adultsQ.
    Astrocytoma - Glioblastoma multiforme is most common
  3. Location of Astrocytoma in children and adults?
    • Supratentorial in adults
    • Infratentorial in childrenQ•
    • Majority of astrocytomas are low-grade in children and high grade in adulthoodQ.
  4. MC posterior fossa tumor in childrenQ•?
    • Astrocytoma
    • In children, pilocytic astrocytoma is most commonQ.•
    • In adults, diffuse astrocytoma is most commonQ.
  5. Radiological features of Glioblastoma?
    Glioblastoma is highly vascular, sometimes so vascular that it resembles an AV malformation on angiography
  6. WHO Classification of Astrocytoma?
    • Grade I or Pilocytic Astrocytoma
    • Low-grade, or grade II astrocytomas
    • Grade III or Anaplastic
    • Grade IV or Glioblastoma multiforme
  7. Radiological featues of pilocytic astrocytoma?
    Discrete appearing, contrast enhancing and often cystic with a mural noduleQ
  8. Treatment of astrocytoma?
    • Pilocytic - Curable by radical resectionQ (no infiltration of surrounding brain), Radiation therapy and chemotherapy have no role
    • Low-grade - Observation and follow-up, radiation with or without chemotherapy, and surgery. Surgery is not curative because most of these tumors are infiltrative with no clear marginsQ
    • Anaplastic and GBM - Cytoreductive surgery followed by EBRTQ.
  9. Histology of Glioblastoma multiforme?
    Endothelial proliferation or necrosisQ on histology makes the tumor grade IV.
  10. Chemotherapy for GBM?
    • Carmustine and cisplatin
    • TemozolomideQ
  11. MC astrocytomas in childhood?
    Juvenile Pilocytic Astrocytoma (JPA)
  12. Most common site of subependymal giant cell astrocytoma?
    • Ependymal wall of lateral ventricle near the foramen of MonroQ -
    • Causes obstruction at the foramen of Monro leading to ventricular enlargement and raised ICT.
  13. Common locaton of Medulloblastoma?
    • Highly malignant tumor found in cerebellumQ and infratentorial location
    • Occur predominantly in childrenQ (peak incidence at 3-4 yearsQ) •
  14. Most radiosensitive brain tumor?
    Most radiosensitive brain tumorQ
  15. Treatment of medulloblastoma?
    • Despite of extreme radiosensitivity, it should be surgically excisedQ.
    • • Surgical excision should be followed by radiotherapy and chemotherapyQ
  16. Side effects of Craniospinal Irradiation (CSI)?
    • GH disturbance – MC side effect
    • Hypothyroidism: One of the earliest late side effects
    • and after GH disturbanceQ
    • Prevalence of hypothyroidism is 40–80% after CSIQ
    • Significantly increased risk of development of benign thyroid nodules and papillary carcinoma of the thyroid many years laterQ..
Card Set
MCQ - Neurosurgery - Brain tumors II
Brain tumors