Pancreatic & G.I. Oncology

  1. Neuropathy
    disease or dysfunction of one or more peripheral nerves, typically causing numbness or weakness in hands and feet
  2. Chemotherapy is particularly dangerous for the liver meaning it is _______
  3. Bilirubin
    an orange-yellow pigment formed in the liver by the breakdown of hemoglobin and excreted in bile. *also aids in the digestion of food
  4. Colon cancer can lead to perforation of the peritoneal cavity which leads to _______
  5. Pancreatic cancer is a highly ______ malignancy, the ______ leading in cancer-related deaths in the U.S.
    • lethal
    • fourth
  6. Pancreatic cancer is second only to _______ cancer as a cause of digestive cancer-related death.
  7. ______ ______ is the only potentially curative treatment for pancreatic cancer
    Surgical resection
  8. ______ presentation is characteristic of pancreatic cancer and prognosis is still _____ even after complete resection. In addition only 15-20% are candidates for _________
    • Late
    • poor
    • pancreatectomy
  9. pancreatectomy
    surgical removal of the pancreas
  10. The commonly used term pancreatic cancer usually refers to a _____ ________ of the pancreas including(its sub-types), which represents about ____ percent of all pancreatic neoplasms.
    • ductal adenocarcinoma
    • 85
  11. adenocarcinoma
    a malignant tumor formed from glandular structures in epithelial tissue.
  12. Of the several sub-types of ductal adenocarcinoma, most share a similar ____ long-term prognosis, with the exception of _____ carcinomas, which have a _____ prognosis.
    • poor
    • colloid 
    • better
  13. The more inclusive term "exocrine pancreatic neoplasms" includes all tumors that are related to the _______ _______ and _____ cells and their ______ cells (including pancreatoblastoma), and is preferred.
    pancreatic ductal and acinar cells
  14. More than 95% of malignant neoplasms of the pancreas arise from the _______ elements. Neoplasms arising from the ______ pancreas (pancreatic neuroendocrine [islet cell] tumors) comprise no more than 5% of pancreatic neoplasms.
    • exocrine
    • endocrine
  15. The most common presenting symptoms in patients with exocrine pancreatic cancer are _____, ______ and _____ loss.
    pain, jaundice and weight loss
  16. In a multi-institutional series of 185 patients with exocrine pancreatic cancer diagnosed over a three year period found the top 8 symptoms at diagnosis were
    • asthenia
    • weight loss
    • anorexia
    • abdominal pain
    • epigastric pain
    • dark urine
    • jaundice
    • nausea
    • back pain 
    • diarrhea vomiting 
    • steatorrhea
    • thrombophlebitis
  17. In general, the most frequent signs were (7)
    • jaundice
    • hepatomegaly
    • right upper quadrant mass 
    • cachexia
    • courvoisier's sign 
    • epigastric mass
    • ascites
  18. asthenia 
    • asthenia: abnormal physical weakness/lack of energy
    • jaundice: yellowing of liver, eyes, skin through biliary tree either intrapatically or extrapatically
    • steatorrhea: fatty stools
  19. The pancreas creates enzymes to help digest fats, _______ becomes possible when these enzymes are compromised
  20. hepatomegaly
    courvoisier's sign
    • hepatomegaly: enlarged liver
    • cachexia: aka wasting syndrome, it is a general state of ill health w/ weight or muscle loss
    • courvoisier's sign: enlarged gall bladder
    • ascites: accumulation of fluid (pale, clear and yellow) in the peritoneal cavity (abdomen)
  21. Hydronephrosis
    kidney retains filtrate/fluid due to blockages "kinks"
  22. Hydronephrosis can lead to ________ which leads to _______ failure
    • distention
    • kidney failure
  23. distention
    swollen due to pressure from within; bloated
  24. kidney stones
    crystallized calcium deposits in kidney, ureter, urethra
Card Set
Pancreatic & G.I. Oncology
Day 1