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Tight Junctions
Seal gaps between epithelial cells via non-covalent bonds between homophillic adhesion proteins (claudins, occludins)
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Adherens Junction
- Cell-cell anchoring junction that links epithelial cells together by binding to their actin filaments
- Adhesion: Classical cadherins
- Adaptor: A, B, Y, p120, vinculin
- Filament: actin
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Desmosomes
- Cell-cell anchoring junction that links epithelial cells together by binding to their intermediate filaments
- Adhesion: Non-classical (Desmocollin, desmoglein)
- Adaptor: Plakoglobin, plakophillin, desmoplakin
- Filament: Intermediate
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Focal connections
- Cell-matrix anchoring junctions that link epithelial cells to underlying ECM proteins of basal lamina by binding to actin filament
- Adhesion: Dimeric integrin
- Adaptor: Vinculin, talin
- Filament: Actin
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Hemidesmosomes
- Cell-matrix anchoring junctions that link epithelial cells to underlying ECM proteins by binding to intermediate filaments
- Adhesion: dimeric integrins
- Adaptor: plectin, dystonin
- Filament: intermediate
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