Home
Flashcards
Preview
Exam 5 - Chapter 33 - NSAIDs
Home
Get App
Take Quiz
Create
Automatically remove your image background. Try it now!
https://remove-image-background.com
COX-1 is found in all tissues and promotes what?
↓ gastic acid secretion
↑ renal blood flow
regulates smooth muscle tone in blood vessels and bronchial tree
What is the purpose of COX-2?
forms after tissue injury
promotes inflammation
What is histamine?
a chemical mediator of inflammation
What are the signs and symptoms of histamine activation?
causes vasodilation
smooth-muscle contraction
tissue swelling
itching
What is the purpose of the inflammatory response?
limits spread of antigen
contains injury
destroys microorganism
What is the mechanism of action of ibuprofen (Advil)?
treats inflammation by inhibiting bot COX-1 and COX-2
What are the adverse effects of ibuprofen (Advil)?
N/V
heartburn
epigastric pain
dizziness
bleeding
MAX 3200 mg/day
What are the labs monitored for NSAID's?
BUN
Creatinine
LFT's
PT/INR
What is the action of prednisone (Meticorten)?
metabolized to an active form of glucocorticoid
What are the adverse effects of prednisone (Meticorten)?
Cushing's syndrome
hyperglycemia
weight gain
mood changes
ulcers, cataracts
muscle weakness
bruising
bone fractures - pulls Ca+ out of bones
Drug-Drug interactions
What is the daily dosing limits of ibuprofen (Advil)?
3200 mg/day
1200 mg/day with liver impairment
What are the daily dosing limits of acetaminophen (Tylenol)?
FDA recommends max dose 325 mg vs 500 mg
What is the purpose of the steps of inflammation?
to neutralize foreign agents
COX-1 is considered good or bad?
Good
If we inhibit COX-1 what happens
GI upset
↓ renal fx
↑ bleeding
Are COX-2 prostaglandins considered good or bad?
Bad
What happens if we inhibit COX-2?
suppresses inflammation
What drug class is aspirin?
Salicylates
Nursing considerations of NSAIDS
LFT's, CBC, PT
assess for ↓ pain and temp
assess for salicylate toxicity (ototoxicity)
Automatically remove your image background. Try it now!
https://remove-image-background.com
Author
cbennett
ID
330472
Card Set
Exam 5 - Chapter 33 - NSAIDs
Description
Exam 5 - Chapter 33 - NSAIDs
Updated
2017-04-18T02:12:04Z
Show Answers
Home
Flashcards
Preview