Exam 5 - Chapter 33 - NSAIDs

  1. COX-1 is found in all tissues and promotes what?
    • ↓ gastic acid secretion
    • ↑ renal blood flow
    • regulates smooth muscle tone in blood vessels and bronchial tree
  2. What is the purpose of COX-2?
    • forms after tissue injury
    • promotes inflammation
  3. What is histamine?
    a chemical mediator of inflammation
  4. What are the signs and symptoms of histamine activation?
    • causes vasodilation
    • smooth-muscle contraction
    • tissue swelling
    • itching
  5. What is the purpose of the inflammatory response?
    • limits spread of antigen
    • contains injury
    • destroys microorganism
  6. What is the mechanism of action of ibuprofen (Advil)?
    treats inflammation by inhibiting bot COX-1 and COX-2
  7. What are the adverse effects of ibuprofen (Advil)?
    • N/V
    • heartburn
    • epigastric pain
    • dizziness
    • bleeding
    • MAX 3200 mg/day
  8. What are the labs monitored for NSAID's?
    • BUN
    • Creatinine
    • LFT's
    • PT/INR
  9. What is the action of prednisone (Meticorten)?
    metabolized to an active form of glucocorticoid
  10. What are the adverse effects of prednisone (Meticorten)?
    • Cushing's syndrome
    • hyperglycemia
    • weight gain
    • mood changes
    • ulcers, cataracts
    • muscle weakness
    • bruising
    • bone fractures - pulls Ca+ out of bones
    • Drug-Drug interactions
  11. What is the daily dosing limits of ibuprofen (Advil)?
    • 3200 mg/day
    • 1200 mg/day with liver impairment
  12. What are the daily dosing limits of acetaminophen (Tylenol)?
    FDA recommends max dose 325 mg vs 500 mg
  13. What is the purpose of the steps of inflammation?
    to neutralize foreign agents
  14. COX-1 is considered good or bad?
    Good
  15. If we inhibit COX-1 what happens
    • GI upset
    • ↓ renal fx
    • ↑ bleeding
  16. Are COX-2 prostaglandins considered good or bad?
    Bad
  17. What happens if we inhibit COX-2?
    suppresses inflammation
  18. What drug class is aspirin?
    Salicylates
  19. Nursing considerations of NSAIDS
    • LFT's, CBC, PT
    • assess for ↓ pain and temp
    • assess for salicylate toxicity (ototoxicity)
Author
cbennett
ID
330472
Card Set
Exam 5 - Chapter 33 - NSAIDs
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Exam 5 - Chapter 33 - NSAIDs
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