metastatic tumor. from lung, breast, lymphoma, leukemia, melanoma, carcinomas of colon & liver
rhabdomyoma. most common primary cardiac tumor in infants/children. Tan, round tumor in L ventricle, of myocardial cell origin
microscopic polyangiitis
pANCAs, MPO protein, Necrotizing glomerulonephritis and pulmonary capillaritis are common, Segmental fibrinoid necrosis of media, Little or no Ig seen in most lesions (pauci-immune injury)
Anti-endothelial Abs
assoc w/ or predispose to Kawasaki dz. Delayed type hypersensitivity T cell response. PAN-like, not much of fibrinoid necrosis as in PAN. Mucocutaneous lymph node syndrome. Conjunctival and oral erythema, edema of hands and feet, erythema of palms and soles
Giant cell (Temporal) Arteritis
T cell mediated, granulomatous formation, noninfectious, fragmentation of internal elastic lamina, nodular intimal thickening
Takayasu arteritis
granulomatous of medium & larger arteries, ocular disturbances, weakened pulses in upper extremities (pulseless dz). Transmural fibrous thickening of aorta. Most frequent in women under 40, more assoc w/ Japanese. Intimal hyperplasia, only difference from giant cell arteritis is AGE of onset
most common hemangioma. Occur in
skin, subcutaneous tissues, mucous membranes of oral cavities and lips, liver,
spleen, kidneys.
most common. Occur in
skin, subcutaneous tissues, mucous membranes of oral cavities and lips, liver,
spleen, kidneys
Capillary hemangioma
Common capillary hemangioma in newborns
juvenile/strawberry hemangioma
neck or axilla of children. Rarely in retroperitoneum. common in neck region of Turner syndrome (may fill axilla). Lesions not encapsulated
Cavernous/cystic lymphangioma
vascular ectasia that grows w/ child, no tendency to fade. (Sturge-Weber syndrome if distribution along trigeminal nerve)
port wine stains
what contributes to Spider telangiectasia?
elevated estrogen
Bacillary angiomatosis
opportunistic infection. Gram negative bartonella (henselae in cat scratch and Quintana in trench fever). Vascular proliferations on skin, bone, brain
No lines of Zahn in ..
organized thrombus
Infarct reaches its full size in
3-6 hrs
contraction bands, loss of nuclei, beginning of inflamm. May also see hemorrhage
1-2 days post MI
Heavy polymorphonuclear infiltrate in area of acute MI
1-3
myocardial rupture most common ____ days post MI
6
Nearly complete removal of necrotic myocytes by phagocytosis: ___ days post MI
3-4
Granulation tissue characterized by loose collagen and abundant capillaries: ____ _____ post MI
1-2 weeks
No onion skinning. Intimal proliferation. Onion skinning normally seen in kidneys, not in lungs. Fibrinoid necrosis is pink due to deposition of plasma proteins. Seen in vasculitis
pulmonary hypertension. cor pulmonale
pulmonary hypertension/cor pulmonale
Acute pulmonary hypertension
dilated R ventricle, no wall thickening
Chronic pulmonary hypertension
both ventricles may be dilated, R ventricle almost as thick as L
