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DRUGS ibhs test 1

  1. context: Topoisomerase (Skacel)

    Fluoroquinolones (antibacterial)
    • inhibits bacterial GYRASE
    • -topoisomerase
  2. context: Topoisomerase (Skacel)

    Irinotecan (chemotherapeutics)
    • inhibits eukaryotic topoisomerase 1
    • -inhibits DNA replication and transcription
    • -colon cancer cocktail
  3. context: toxins to G proteins (Bryant)
    Cholera (intestinal infection)
    • abolishes GTPase activity in Gs protein
    • = excess Cl- lost = water loss
    • ex: diarrhea, dehydration
  4. context: toxins to G proteins (Bryant)
    Pertussis (whooping cough)
    • Locks Gi in GDP-bound state
    • = decrease immune cells activity, paralyze respiratory cilia = infection, inflammation, coughing
  5. Context: GPCR DRUGS (Bryant)
    Sumatriptan
    • migraine
    • Serotonin - 5HT1b/1d
    • (if it has a P in name = Serotonin)
  6. Context: GPCR DRUGS (Bryant)
    Buspirone
    • anxiety
    • Serotonin- 5HT1a
    • (if it has a P in name = Serotonin)
  7. Context: GPCR DRUGS (Bryant)
    Olanzapine
    • psychosis
    • Serotonin - 5HT2
    • (if it has a P in name = Serotonin)
  8. Context: GPCR DRUGS (Bryant)
    Cisapride
    • Nocturnal Heartburn
    • Serotonin - 5 HT4
    • (if it has a P in name = Serotonin)
  9. Context: GPCR DRUGS (Bryant)
    Clozapine
    • Schizophrenia
    • Serotonin - mixed
    • (if it has a P in name = Serotonin)
  10. Context: GPCR DRUGS (Bryant)
    Timolol
    • Glaucoma/hypertension
    • Adrenergic Beta-mixed
  11. Context: GPCR DRUGS (Bryant)
    Atenolol
    • hypertension
    • Adrenergic beta 1
  12. Context: GPCR DRUGS (Bryant)
    Albuterol
    • Asthma
    • Adrenergic beta -2
  13. Context: GPCR DRUGS (Bryant)
    doxazosin
    • hypertension/prostatitis
    • adrenergic- alpha
  14. Context: GPCR DRUGS (Bryant)
    carvedilol
    • congestive heart failure
    • adrenergic - beta- 1,2 alpha 1
  15. context: enzyme-linked receptors LIGANDS (Bryant)
    Insulin
    drugs?
    • *increase glucose intake for diabetics
    • Humalog,
    • humulin,
    • lantus
  16. context: enzyme-linked receptors LIGANDS (Bryant)
    Growth factor
    drugs?
    • *increases RBC production for anemics
    • Erythropoietin (EPO)
  17. context: enzyme-linked receptors LIGANDS (Bryant)
    Cytokine
    drugs?
    • *TNF (Tumor Necrosis factor) stimulate inflammation and cell death
    • anti-tumor agent
  18. context: kinase receptors [enzyme-linked receptors] LIGANDS (Bryant)
    Sprycel (dasaTINIB)
    • leukemia (White Blood Cell cancer)
    • binds to a kinase in the kinase cascade
    • inhibits src kinase = stops phosphorylation
  19. context: kinase receptors [enzyme-linked receptors] LIGANDS (Bryant)
    Tykerb (lapaTINIB)
    • for breast cancer
    • binds to kinase domain on kinase receptor (epidermal growth factor receptor)
    • prevents AUTOphosphorylation
  20. context: ion channel-linked/ionotropic/ligand-gated receptors LIGANDS (Bryant)
    Curare derivatives
    • antagonist for ACh (nicotinic)
    • relax muscle during surgery
  21. context: ion channel-linked/ionotropic/ligand-gated receptors LIGANDS (Bryant)
    Ondansetron
    • antagonist for Serotonin (5HT3)
    • anti-emitic for cancer patients (no vomiting)
  22. context: ion channel-linked/ionotropic/ligand-gated receptors LIGANDS (Bryant)
    Memantine (NAMENDA)
    • antagonist for Glutamate (NMDA)
    • reduces cell death in Alzheimers
  23. context: ion channel-linked/ionotropic/ligand-gated receptors LIGANDS (Bryant)
    ClonazepAM
    • agonist for GABAA, but not at site.
    • anxiety, seizures, insomnia
  24. context: ion channel-linked/ionotropic/ligand-gated receptors LIGANDS (Bryant)
    DiazepAM
    • agonist for GABAA, but not at site.
    • anxiety, seizures, insomnia
  25. context: ion channel-linked/ionotropic/ligand-gated receptors LIGANDS (Bryant)
    AlpazolAM
    • agonist for GABAA, but not at site.
    • anxiety, seizures, insomnia
  26. context: ion channel-linked/ionotropic/ligand-gated receptors LIGANDS (Bryant)
    LorazepAM
    • agonist for GABAA, but not at site.
    • anxiety, seizures, insomnia
  27. context: ion channel-linked/ionotropic/ligand-gated receptors LIGANDS (Bryant)
    TemazepAM
    • agonist for GABAA, but not at site.
    • anxiety, seizures, insomnia
  28. context: ion channel-linked/ionotropic/ligand-gated receptors LIGANDS (Bryant)
    Topiramate (Topamax)
    • agonist for GABAA, but not at site.
    • anxiety, seizures, insomnia
  29. context: ion channel-linked/ionotropic/ligand-gated receptors LIGANDS (Bryant)
    phenobarbital
    • agonist for GABAA, but not at site.
    • anxiety, seizures, insomnia
  30. context: Intracellular receptors/ NHR (nuclear hormone receptors)/Cytosolic receptors LIGANDS : (Bryant)
    PredniSONE
    • inflammation, allergies, asthma
    • affect Glucocorticoid receptors
  31. context: Intracellular receptors/ NHR (nuclear hormone receptors)/Cytosolic receptors LIGANDS : (Bryant)
    MethylpredniSONE
    • inflammation, allergies, asthma
    • affect Glucocorticoid receptors
  32. context: Intracellular receptors/ NHR (nuclear hormone receptors)/Cytosolic receptors LIGANDS : (Bryant)
    FluticaSONE (Veramyst)
    • inflammation, allergies, asthma
    • affect Glucocorticoid receptors
  33. context: Intracellular receptors/ NHR (nuclear hormone receptors)/Cytosolic receptors LIGANDS : (Bryant)
    MometaSONE (Nasonex)
    • inflammation, allergies, asthma
    • affect Glucocorticoid receptors
  34. context: Intracellular receptors/ NHR (nuclear hormone receptors)/Cytosolic receptors LIGANDS : (Bryant)
    Budesonide (Rhinocort)
    • inflammation, allergies, asthma
    • affect Glucocorticoid receptors
  35. context: Intracellular receptors/ NHR (nuclear hormone receptors)/Cytosolic receptors LIGANDS : (Bryant)
    Conjugated estrogens (Premarin)
    • menopause
    • affect Estrogen receptor
  36. context: Intracellular receptors/ NHR (nuclear hormone receptors)/Cytosolic receptors LIGANDS : (Bryant)
    Ethinyl Estradiol/Norelgestromin (OrthoEvra)
    • contraception
    • affect estrogen and progesterone receptors
  37. context: Intracellular receptors/ NHR (nuclear hormone receptors)/Cytosolic receptors LIGANDS : (Bryant)
    Ethinyl Estradiol/Drospirenone (Yasmin 28, Yaz)
    • contraception
    • affect estrogen and progesterone receptors
  38. context: Intracellular receptors/ NHR (nuclear hormone receptors)/Cytosolic receptors LIGANDS : (Bryant)
    Ethinyl Estradiol/Norgestimate (Ortho Tri-Cyclen Lo)
    • contraception
    • affect estrogen and progesterone receptors
  39. context: Intracellular receptors/ NHR (nuclear hormone receptors)/Cytosolic receptors LIGANDS : (Bryant)
    Ethinyl Estradiol/Levonorgestrel (Aviane)
    • contraception
    • affect estrogen and progesterone receptors
  40. context: Intracellular receptors/ NHR (nuclear hormone receptors)/Cytosolic receptors LIGANDS : (Bryant)
    Levothyroxine (Synthroid, Levoxyl, Levothroid)
    • hypothyroidism
    • affect Thyroid hormone receptor
Author
VASUpharm14
ID
32969
Card Set
DRUGS ibhs test 1
Description
DRUGS to know on test 1
Updated

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