Chapter 10 - Opioids

  1. opioids
    psychoactive substances that elicit pharmacological effects by acting on opioid receptors in the CNS and other parts of the body
  2. naturally occurring opioids
    opioids found in opium, including morphine and codeine
  3. fully synthetic opioids
    opioids are not derived from morphine, codeine, or any other naturally occurring opioid
  4. G-protein-coupled inwardly rectifying K+ channel (GIRK)
    A K+ channel that causes the influx of K+ when a neuron is hyperpolarized and less K+ influx when a neuron is depolarized
  5. pure opioid receptor agonists
    drugs that act as full receptor antagonists at mu opioid receptors
  6. partial opioid receptor agonists
    drugs that produce partial agonist actions at mu opioid receptors and therefore do not produce the same magnitude of pharmacological effects achieved by pure opioid receptor agonists
  7. pure opioid receptor antagonists
    drugs that act as full receptor antagonists at mu opioid receptors
  8. mixed opioid receptor agonist-antagonists
    drugs that exhibit agonist actions at some opioid receptors while exhibiting antagonist actions at other opioid receptors
  9. conditioned place preference
    an organism associates a unique environment with a drug's reinforcing effects
  10. miosis
    pupil constriction that can occur after opioid administration
  11. detoxification
    process that uses an opioid agonist or antagonist to reduce withdrawal symptoms
  12. long-term opioid detoxification
    detoxification process that lasts approximately 180 days and occurs by prescribing and opioid receptor agonist or a partial opioid receptor agonist to replace the illicit opioid drug
  13. short-term opioid detoxification
    detoxification process that lasts as long as 30 days and usually uses opioid receptor agonists
  14. rapid detoxification
    detoxification process lasting as along as 10 days and using opioid antagonist administration in a treatment facility
  15. ultrarapid opioid detoxification
    detoxification process lasting as long as 2 days and using opioid antagonist administration in a hospital setting
Author
AbbyKrish
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329409
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Chapter 10 - Opioids
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