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Metabolism (2)
- The totality of an organism's chemical reactions
- Transforms matter and energy, subject to the laws of thermodynamics
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Metabolic Pathway
Begins with a specific molecule and ends with a product, and each step is catalyzed by a specific enzyme
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Catabolic Pathways
Release energy by breaking down complex molecules into simpler compound
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Cellular Respiration
A catabolic pathway in which glucose is broken down in the presence of oxygen
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Anabolic Pathways
Consume energy to build complex molecules from simpler ones
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Bioenergetics
The study of how energy flows through organisms
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Energy (2)
- Capacity to cause change
- Can be converted from one form to another
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Kinetic Energy
Energy associated with motion
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Potential Energy
Energy that matter possesses because of its location or structure
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Chemical Energy
Potential energy available for release in a chemical reaction
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Thermodynamics
The study of energy transformations
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Isolated System
Energy and matter cannot be transferred between the system and its surroundings
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Open System (2)
- Energy and matter can be transferred between the system and its surroundings
- Ex: Organisms
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First Law of Thermodynamics (2)
- The energy of the universe is constant
- It can be transferred and transformed, but it can't be destroyed
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Second Law of Thermodynamics
Every energy transfer or transformation increases the entropy (disorder) of the universe
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Free Energy
Energy that can do work when temperature and pressure are uniform, as in a living cell
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- ΔG (2)
- Spontaneous process
- Can be harnessed to perform work
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Equilibrium (3)
- State of maximum stability
- A process is spontaneous and can perform work only when it is moving toward equilibrium
- Metabolism is never at equilibrium
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Exergonic Reaction
Proceeds with a net release of free energy and is spontaneous (-ΔG)
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Endergonic Reaction
Absorbs free energy from its surroundings and is nonspontaneous (+ΔG)
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Energy Coupling (3)
- The use of an exergonic process to drive an endergonic one
- Used by cells to manage energy resources
- Mediated by ATP
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Catalyst
Chemical agent that speeds up a reaction without being consumed by the reaction
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Activation Energy
The initial energy needed to start a chemical reaction
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Substrate
The reactant that an enzyme acts on
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Enzyme-substrate complex
Formed after the enzyme binds to its substrate
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Active site
- The region of the enzyme where the substrate binds
- Can lower the activation energy barrier
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Cofactors
- Nonprotein enzyme helpers
- May be organic or inorganic
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Coenzyme (2)
- An organic cofactor that is required by an enzyme
- i.e vitamins
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Competitive Inhibitor
Something that binds to the active site of an enzyme preventing the substrate from binding
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Noncompetitive inhibitor (3)
- Bind to a part of the enzyme that isn't the active site causing the enzyme to lose shape
- Makes the active site less effective/accessible
- Ex: toxins, poisons, pesticides, antibiotics
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Allosteric Regulation
- Can either inhibit or stimulate an enzyme's activity
- Occurs when a regulatory molecule binds to a protein at one site and affects the proteins function at another
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Allosteric Regulators
DO NOT bind to the active site of an enzyme
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Allosteric Activators
Bind to the enzyme and stabilize the active form
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Allosteric Inhibitors
Bind to the enzyme and stabilize the inactive form of the enzyme
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Feedback Inhibition (2)
- The end product of a metabolic pathway inhibits an enzyme in the pathway, shutting down the pathway
- Prevents a cell from wasting resources by synthesizing more product than is needed
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