1. Home
  2. Flashcards
  3. Preview

Therapeutics III - Pregnancy and Lactation

  1. What are causes of teratogenicity?
    • 1. genetic
    • 2. chromosomal abnormality
    • 3. environmental
    •      -chemicals
    •      -infections
    •      -maternal metabolic imbalance
    •      -drugs
    • 4. multifactorial
  2. What are the critical times for common issues:
    • 20-55 days post conception
    • -up to 30 days: neural tube defects
    • -up to 36 days: cleft lip
    • -up to 10 weeks: cleft palate
    • -up to 6 weeks: ventral septal defect
  3. What are key factors in determining risk?
    • 1. exposure at critical time
    • 2. specific defect or syndrome
    • 3. consistent findings in ≥2 epidemiologic studies (or rare finding + rare defect)
    • 4. animal data
    • 5. biologic plausibility
    • 6. secular trends
    • 7. data on drugs in the same class
  4. What are factors that influence placental transfer of biological agents and medications?
    • 1. maternal concentration
    • 2. molecular weight
    • 3. pH (fetal pH slightly more acidic than maternal)
    • 4. Lipid solubility
  5. What type of transfer do MOST but not all biological agents use to transfer to placenta?
    passive diffusion
Author
mbailey585
ID
328965
Card Set
Therapeutics III - Pregnancy and Lactation
Description
Therapeutics III - Pregnancy and Lactation
Updated

  1. Home
  2. Flashcards
  3. Preview