Genome Structure part 3

histone acetyl-transferases (HATs)
- enzymes that add acetyl groups to histones
- an integral part of transcription initiation
- Adding acetyl will remove the + charge and make the chromatin less condensed
histone deacetylases (HDACs)
- group of enzymes that remove the acetyl group from the histone tails
- Gene inactivation is partly the function of HDACs
Proteins interacting with methylated histone are involved in __
- suppression of transcription and generation of heterochromatin
- makes chromatin more condensed
__ of __ will activate transcription & __ will suppress transcription
- Acetylation;
- lysines of H3 & H4;
- methylation
Acetylation and phosphorylation __ of histone tails, which causes __
- reduce the positive charge;
- less affinity of the histone tails for DNA
Formation of __ requires the histone tails. Chemical modification of the tail __
- 30mm fiber;
- decreases the ability to make higher order structures of chromatin (which usually represses transcription)
Modification of histones generate binding sites for __. These interacting proteins recruit other proteins that __

more of and other chromatin modifying enzymes; modify adjacent histones → maintenance and propagation of the modifications (e.g. HATs)

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sophathida

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Card Set

Genome Structure part 3

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Week 4

Updated

2017-02-08T04:40:13Z

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