M01 - Immunology and Autoimmune Disease

  1. Match the following disorders to the antibody with which it is associated. Answers can only be used once.

    +Systemic Lupus Erythematosus
    +Rheumatoid Arthritis
    +Hashimoto's thyroiditis
    +Graves' disease
    +Celiac disease
    +Sjogren's syndrome

    -anti-TSH receptor antibody
    -anti-thyroglobulin antibody
    -anti-Scl antibody
    -anti-CCP (cyclic citrullinated peptide)
    -anti-SSA and SSB antibodies
    -anti-tTGA (tissue transglutaminase)
    • Systemic Lupus Erythematosus: anti-dsDNA
    • Rheumatoid Arthritis: anti-CCP (cyclic citrullinated peptide)
    • Hashimoto's thyroiditis: anti-thyroglobulin antibody
    • Graves' disease: anti-TSH receptor antibody
    • Celiac disease: anti-tTGA (tissue transglutaminase)
    • Sjogren's syndrome: anti-SSA and SSB antibodies
    • Scleroderma: anti-Scl antibody
    • Polymyositis: anti-Jo-1
  2. Macrophages that migrate to the liver are called:

    B)  Kupffer cells
  3. (T/F) After infection with EBV or HSV, T cells have receptors which cross-react with myelin basic protein, a basic component of the myelin sheath of nerves in the CNS, causing the symptoms of multiple sclerosis.
  4. (T/F) Oligoclonal bands present in CSF protein electrophoresis but absent in serum protein electrophoresis of a patient is diagnostic for MS.
  5. Which of the following helps protect against helminth infection?

    C)  Eosinophils
  6. If a patient has IgM antibodies to the mumps virus, this indicates they have

    B)  an acute or very recent mumps infection.
  7. In the anti-dsDNA fluorescent antibody screening test the antigen most commonly utilized is:

    A)  Crithidia luciliae
  8. The function(s) of macrophages/monocytes in the host immune response is (are):

    A)  all the above
  9. The purpose or end result of negative selection of the T cell is to ensure:

    C)  self-tolerance
  10. Which of the following is true of NK cells?

    D)  They kill tumor and virus-infected cells.
  11. Cells that are precursors of plasma cells and also produce immunoglobulins are

    D)  B lymphocytes
  12. The technologist observes apparent homogenous staining of the nucleus of interphase cells while performing an IFA-ANA, as well as staining of the chromosomes in mitotic cells. This result is:

    A)  expected for anti-DNA antibodies
  13. Macrophage phagocytosis of bacteria is enhanced by which of the following

    D)  opsonin
  14. All of the following are functions of immunoglobulins except

    A)  interacting with T cells to lyse viruses
  15. (T/F) The presence of anti-Smith antibodies is diagnostic for systemic lupus erythematosus.
  16. SLE can be distinguished from RA on the basis of which of the following?

    A)  anti-dsDNA antibodies
  17. Which of the following best describes the slide agglutination test for rheumatoid factor?

    D)  it is a sensitive screening tool
  18. Toll-like receptors are found on which cells?

    A)  Dendritic cells
  19. A specimen was drawn from a 25-year-old woman with suspected SLE. A FANA screen revealed a speckled pattern. What should be done next?

    B)  perform an antibody profile
  20. Which of the following is cleaved as a result of activation of the classical complement pathway?

    A)  C4
  21. Compare and contrast the "sequestered antigen" and the "molecular mimicry" theories of autoimmune disease.
    The sequestered antigen theory proposes that damage to certains tissues or organs exposes previously separated of hidden antigens thatmay be identified as foreign antigens since they have not been encountered by the host immune system before. The molecuar mimicrytheory is based on smilarities between pathogen and self antigens that may induce a cross reaction from host made antibidoes originallyproduced to respond to infection from such pathogens. Both theroires result in a loss of self tolerance where the host immunesystem recognizes, and attacks self antigens. Molecular mimicry is associated with infectious disease states while mimicry is more related totrauma and injury. Though diseases can cause tissue and organ damage.
  22. The immunoglobulin classes MOST commonly found on the surface of circulating B lymphocytes in the peripheral blood of normal persons are:

    C)  IgM, IgD
  23. (T/F) Systemic lupus erythematosus is associated with the DR3 HLA type.
  24. The assembly of the complement "membrane attack unit" is initiated with the binding of:

    C) C5
  25. Which immunoglobulin appears in highest titer in the secondary response?

    D) IgG
  26. A homogeneous pattern of staining of the nuclei on IIF may be caused by which of the following antibodies?

    D)  anti-histone antibody
  27. Which immunoglobulin appears first in the primary immune response?

    D) IgM
  28. Which immunologic mechanism is usually involved in bronchial asthma?

    A)  immediate hypersensitivity
  29. (T/F) Type 1 diabetes (juvenile diabetes) often occurs after a viral infection and is an example of the molecular mimicry theory of autoimmunity.
  30. Natural killer cells destroy invading organisms by

    D)  releasing cytotoxic perforins and granzymes
  31. A new-born infant who receives IgA from it's mother's milk develops

    B)  naturally acquired passive immunity
  32. Rheumatoid factor is:

    C)  IgM antibody produced against IgG
  33. T lymphocytes that possess the CD8 surface marker mediate which of the following T cell functions?

    B)  cytotoxic
  34. Measurement of serum levels of which of the following immunoglobulins can serve as a screening test for multiple allergies?

    B) IgE
  35. Which of the following is an important cellular mediator in immune complex tissue injury?

    A)  neutrophil
  36. (T/F) T cells can only see and respond to antigens when they are combined with MHC molecules.
  37. Select the answer that does NOT apply to class II MHC molecules:

    B)  Class II MHC molecules present viral antigens to CD8+ T cells
  38. (T/F) Class I and Class II MHC molecules determine the type of peptide antigens to which an individual can mount an immune response.
  39. Which antibody class is best at agglutination and complement fixation?

    A) Igm
Card Set
M01 - Immunology and Autoimmune Disease
M01 - Immunology and Autoimmune Disease