CHEM06 - Endocrinology and Bone Metabolism

  1. An example of a hormone that circulates bound to a carrier protein is

    B) T4
  2. In the negative feedback loop between the adrenal gland and the pituitary, an increase in cortisol would result in

    C)  a decrease in ACTH
  3. Increased ACTH and potassium, along with decreased cortisol, aldosterone and sodium would be consistent with:

    B)  Addison's disease
  4. In a patient who is suspected of having pheochromocytoma, which of the following analytes would you recommend to a physician?

    A)  Urine Metanephrines
  5. To estimate plasma renin, we can quantitate the production of {select} by its enzymatic activity.

    C)  angiotensin I
  6. Which of the following is the mechanism causing Cushing's disease?

    D)  Excess secretion of pituitary ACTH
  7. The disease characterized by primary hyperaldosteronism resulting from adrenal adenoma, carcinoma, or hyperplasia is:

    D)  Conn's disease
  8. Which statement regarding thyroid hormones is true?

    A)  T3 is about 10 times more active than T4.
  9. Select the most appropiate single screening test for thyroid disease.

    D) TSH
  10. A very low TSH level would be characteristic of:

    A)  Primary hyperthyroidism
  11. A patient has a suppressed TSH and normal free T4. A medical student is confused by these results. What follow up test might you suggest?

    E)  Total T3
  12. Which of the following is an autoantibody that binds to and activates TSH receptor sites on thyroid cell membranes?

    A)  Thyroid stimulating immunoglobulin
  13. Which of the following is an autoimmune disorder that commonly results in hypothyroidism?

    B)  Hashimoto's thyroiditis
  14. Releasing hormones are produced by the

    A)  hypothalamus
  15. A patient with possible Hashimoto's thyroiditis should be tested for which marker?

    C)  Anti thyroid peroxidase (anti TPO)
  16. When testing for thyroglobulin levels, you should also include testing for

    A)  anti thyroglobulin antibodies.
  17. Insulinlikegrowth factor 1 (IGF1)is secreted in direct response to

    C)  Growth hormone
  18. Match the following sex hormones with their function (none are used twice).

    +Prepares endometrium for implantation
    +Increases after ovulation, maintains endometrium
    +Maintains corpus luteum to synthesize progesterone and estrogen
    +Stimulates ovulation and formation of corpus luteum
    +Promotes maturation of ova
    +Induces ductal development in breasts and production of milk
    +Stimulates release of FSH and LH

    -Follice Stimulating Hormone
    -Luteinizing Hormone
    • Prepares endometrium for implantation: Estradiol
    • Increases after ovulation, maintains endometrium: Progesterone
    • Maintains corpus luteum to synthesize progesterone and estrogen: hCG
    • Stimulates ovulation and formation of corpus luteum: Luteinizing Hormone
    • Promotes maturation of ova: Follicle Stimulating Hormone
    • Induces ductal development in breasts and production of milk: Prolactin
    • Stimulates release of FSH and LH: GnRH
  19. Which hormone stimulates the formation of sperm in men?

    D) FSH
  20. You receive a sample in the lab with a request for "vitamin D levels". Which assay would be appropriate for most patients?

    D)  25 OH vitamin D
  21. Which of the following pituitary hormones is NOT considered a trophic hormone?

    D)  Prolactin
  22. For each of the following endocrine organs, pick its trophic hormone and the hormone primarily resulting fromthat stimulation.


    • Adrenal: ACTH/Cortisol
    • Ovary: FSH/Estradiol
    • Testis: LH/Testosterone
    • Thyroid: TSH/T4
  23. The hormones secreted by the posterior pituitary are :

    A)  ADH (AVP)/Oxytocin
  24. (T/F) Prolactin release from the pituitary is normally inhibited by dopamine .
  25. Parathyroid hormone's net action is to

    A)  raise calcium and lower phosphorus in blood.
  26. The laboratory receives blood and a requisition with "ACTH stimulation test, 60 minutes post" handwritten. The test(s) that should be performed on this sample is(are):

    B)  Cortisol
  27. The diurnal variation in cortisol results in normal blood levels

    A)  higher in the morning, lower in the evening
  28. (T/F) The most common type of congenital adrenal hyperplasia results from a deficiency of 21 hydroxylase, resulting in excess production of adrenal androgens . It is typically diagnosed by demonstration of a markedly elevated 17-hydroxyprogesterone in serum.
  29. The TRH (thyrotropin releasing hormone) stimulation test is performed by injecting the patient with TRH, then measuring TSH. This test would be useful in differentiating hypothalamic (tertiary) hypothyroidism from:

    A)  secondary hypothyroidism.
  30. The hormone having the greatest control of serum calcium levels is

    C)  parathyroid hormone (PTH).
  31. After destruction of a thyroid tumor with I131radioablation, what marker is used to determine that no functioning thyroid tissue remains?

    D)  Thyroglobulin
  32. The one hormone exerting positive feedback in the endocrine system is

    A)  estradiol.
  33. An otherwise healthy woman in menopause would be expected to have all of the following EXCEPT:

    A)  Increased progesterone.
  34. Pregnancy tests target the appearance of which marker in blood or urine?

    D) hCG
  35. Serum pregnancy tests can detect pregnancy

    A)  3-5 days before the expected period.
  36. Measurement of testosterone by immunoassay is acceptable in which patient groups:

    C)  male adults
  37. A secretion of some tumors that is responsible for hypercalcemia is:

    A)  PTH-related peptide
  38. In a male patient with hypogonadotropic hypogonadism, you would expect to see

    B)  decreased FSH and decreased testosterone
  39. A 32 y.o. Hispanic female presents with secondary amenorrhea. She is overweight and shows dark facial hair plus acne. She most likely has:

    D)  Polycystic ovary syndrome
  40. The hormone measurement most susceptible to the hook effect is:

    B)  prolactin
  41. A disorder that might arise from a growth hormone secreting tumor developing in a 28 year old male would be

    A)  acromegaly
  42. (T/F) In an overnight dexamethasone suppression test, the lab result that would confirm a hyperadrenal state wouldbe a(n) increased (above a cutoff) 8:00 am Cortisol
  43. A steroid hormone that represents an adrenal androgen is :

    C)  DHEAS (dehydroepiandrosterone sulfate)
  44. How would congenital adrenal hyperplasia (CAH) affect cortisol and adrenal androgen blood levels?

    D)  decreased cortisol, increased adrenal androgens
  45. One of the pituitary hormones could be considered both a direct effector as well as a trophic hormone. Whichis it (1 pt) and why is this true (1 pt)?
    Growth hormone acts directly on tissues (eg bone, soft tissue, etc) and also stimulates other effectors like IGF1 from the liver?
Card Set
CHEM06 - Endocrinology and Bone Metabolism
CHEM06 - Endocrinology and Bone Metabolism