Type 2 DM Medications

  1. This drug enhances insulin secretion from the pancreas

    Known as "insulin secretagogues" or "hypoglycemic agents"

    Long-acting
    Sulfonlyureas
  2. Where do Sulfonlyureas work?
    Pancreas
  3. Examples of Sulfonlyureas
    Amaryl, diabeta, glucotrol
  4. This drug enhances insulin section from the pancreas but a different receptor than sulfonlyureas

    Known as "insulin secretagogues" or "hypoglycemic agents"

    Short-acting
    Meglitinides
  5. Where do Meglitinides work?
    Pancreas but different receptor from sulfonlyureas
  6. Examples of Meglitinides
    Prandin, Starlix
  7. This drug decreased hepatic glucose production and lowers insulin resistance and improves serum TG level

    Known as sensitizers

    Preferred initial pharmacologic agent for type 2 DM
    Biguanides
  8. Where do Biguanides work?
    Liver
  9. Examples of Biguanides
    Metformin
  10. This drug enhances insulin action in liver, muscle and adipose but decreasing insulin resistance

    Known as sensitizers
    Thiazolidinediones (TZDs)
  11. Where do Thiazolidinediones (TZDs) work?
    Liver, muscle and adipose (LAM)
  12. Examples of Thiazolidinediones (TZDs)
    Avandia, Actos (actos could cause bladder cancer tho)
  13. This drug slows digestion and absorption of some CHO in the small intestine and therefore decreases post-prandial glucose peaks
    Alpha-Glucosidase Inhibitors
  14. Where do Alpha-Glucosidase Inhibitors work?
    GI tract--small intestine
  15. Examples of Alpha-Glucosidase Inhibitors
    Precose, Glyset
  16. This drug enhances the incretin system by acting on the alpha and beta cells of the pancreas to regulate glucose

    **Glucose dependent-- insulin only released when BG increases
    DPP-4 Inhibitor
  17. Where do DPP-4 Inhibitors work?
    Pancreas (alpha and beta cells)
  18. Examples of DPP-4 Inhibitors
    Januvia
  19. This drug secrets insulin when BG increases and lowers hepatic glucose output by decreases secretin of glucagon
    GLP-1 Receptor Agonist
  20. Where do GLP-1 Receptor Agonist work?
    liver
  21. Examples of GLP-1 Receptor Agonist
    BYETTA
  22. this drug slows gastric emptying and decreases postprandial glucagon concentrations 

    **Used to control BG in type ONE and type TWO diabetics 
    Amylin Mimetic
  23. Where does Amylin Mimetic work?
    Since is slows gastric empty I'm assuming somewhere in the GI tract
  24. Examples of Amylin Mimetic
    Symlin
Author
arikell
ID
326794
Card Set
Type 2 DM Medications
Description
Exam 3 Material
Updated