Cardiology

  1. What is the MOA of Anti-Arrhytmic Class I medications?
    Fast Sodium Channel Blockers
  2. Name Class 1a Anti-Arrhythmics
    • Quinidine
    • Procainamide
    • Disopyramide
  3. What affect does Class 1a anti-arrhythmics have on the electrical conduction of the heart?
    • Moderate decrease conduction
    • Increased action potential duration
    • Prolong QRS complex
  4. Quinidine is used to treat which arrhythmias?
    • Supraventricular Tachyarrhytmias
    • Ventricular Tachycardia
    • Atrial Fibrillation
  5. What is the MOA of Quinidine
    • Na Channel blocker
    • Decreased Phase 0 depolarization
    • Blocks slow influx of Calcium
    • Delays Potassium current
    • Inhibition of Na/K-ATPase
    • Alpha glycoprotein bound
  6. What are the affects of Quinidine on the ECG
    • Increase QRS Complex
    • Prolonged QT interval
    • Torsades de pointes
  7. How is Quinidine excreted?
    • Cytochrome P450 in the liver
    • 20% unchained in kidneys

    Half life: 6-8 hours
  8. What are the known side effects of Quinidine?
    • Cardio-toxic arrhythmia (Vtach)
    • Increases levels of lidocaine, B-blockers, Opioids
    • Hypotension if bolused
    • CNS symptoms (Seizure, Depression)
    • GIT (Vomiting, Diarrhea)
    • Oliguria
  9. Name the arrhythmias treated with Procainamide
    • VPCs
    • Ventricular tachycardia
    • +/- SVT
  10. What is the MOA of Procainamide
    • Na Channel Blocker
    • Blocks outward K channels
    • Prolongs refractory period Atria and Ventricle
    • Decreased myocardial excitability
    • Decreased automaticity and conduction velocity
    • Anticholinergic effects
  11. What are the affects of Procainamide on the ECG?
    • QRS Widening
    • Prolonged PR and QT intervals
    • Decrease voltage QRS complex & T wave
Author
NattieJ567
ID
325743
Card Set
Cardiology
Description
Cardio Flashcards
Updated