What is the MOA of Anti-Arrhytmic Class I medications?
Fast Sodium Channel Blockers
Name Class 1a Anti-Arrhythmics
What affect does Class 1a anti-arrhythmics have on the electrical conduction of the heart?
Moderate decrease conduction
Increased action potential duration
Prolong QRS complex
Quinidine is used to treat which arrhythmias?
What is the MOA of Quinidine
Na Channel blocker
Decreased Phase 0 depolarization
Blocks slow influx of Calcium
Delays Potassium current
Inhibition of Na/K-ATPase
Alpha glycoprotein bound
What are the affects of Quinidine on the ECG
Increase QRS Complex
Prolonged QT interval
Torsades de pointes
How is Quinidine excreted?
Cytochrome P450 in the liver
20% unchained in kidneys
Half life: 6-8 hours
What are the known side effects of Quinidine?
Cardio-toxic arrhythmia (Vtach)
Increases levels of lidocaine, B-blockers, Opioids
Hypotension if bolused
CNS symptoms (Seizure, Depression)
GIT (Vomiting, Diarrhea)
Name the arrhythmias treated with Procainamide
What is the MOA of Procainamide
Na Channel Blocker
Blocks outward K channels
Prolongs refractory period Atria and Ventricle
Decreased myocardial excitability
Decreased automaticity and conduction velocity
What are the affects of Procainamide on the ECG?
Prolonged PR and QT intervals
Decrease voltage QRS complex & T wave