chapter 11: Iron Metabolism

hemoglobin

ferrous (Fe+3)

ferritin and hemosiderin

• heme: meats,
• nonheme: leafy greens (harder to absorb)

ferrous (Fe2+)

duodenum and jejunum of small intestine

to degrade ferroportin and prevent iron from being absorbed in the plasma

iron goes out of the intestinal cell via basal layer thanks to this guy

hepatocytes. liver

inflammation will cause increase levels of macrophages to have iron in them. Hyperactivity will cause hepcidin levels to increase as well.

Prussian blue

• mitochondria
• hemoglobin
• myoglobin

a protein that enhances the function of ferritin and transferrin by activating its corresponding gene sequence

apoferritin and hemosiderin

the ferritin protein without iron. precursor to ferritin

max storage of oxidized from ferritin. is the parially degraded product of ferritin and appears during iron overload and hemochromatosis

iron metabolism disease where there is excess iron in the tissues

found in the basal layer and reoxidized ferrous to ferric iron

protein associated with iron entering the intestinal cell

measures iron only bound to trasnferring

measuring total ability of iron to bind to transferrin and includes transferrin not bound to iron.

• ferritin is leaked out into the plasma at a cell constant rate and can be used as a measurement for the amount of ferritin in the cell.
• good to distinguish the different types of thalassemia