Chapter 8: Erythropoeisis and destruction

  1. name the stages of erythropoeisis using normoblast
    • pronormoblast
    • basophilic normoblast
    • polychromatic normoblast
    • orthochromic normoblast
    • reticulocyte
    • erythrocyte
  2. what contributes to the blue color of immature erythroblasts
  3. what are the general changes during RBC maturation (3)
    • cell size decreases
    • blue color decreases
    • nucleus condenses and is ejected out
  4. name the rubriblastic maturation stages
    • rubriblast
    • prorubricyte
    • rubricyte
    • metarubricyte
    • reticulocyte
    • erythrocyte
  5. how to ID stem cells as a precursor for RBC
    • RBC mature in groups and colonies called burst forming unit -erythroid (BFU-E) or colony forming unit - erythroid (CFU-E)
  6. what type of test distinguishes CFU-E and BFU-E's
    flowcytometry. bc cannot be visually distinguished
  7. How to ID RBC maturation
    • cell size
    • nucleus
    • cytoplasm color
  8. Name this cell
    Image Upload 1
    • proerythrocyte
    • rubriblast
    • pronormoblast
  9. name the dark cell
    Image Upload 2
    • proerthryocyte
    • rubriblast 
    • pronormoblast
  10. Name this cellImage Upload 3
    • proerythroblast
    • pronormoblast
    • rubricyte
  11. Image Upload 4
  12. Name this cell
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    • proerythroblast
    • pronormoblast
    • rubricyte
  13. Name this cell
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    • proeryrthrocyte
    • rubriblast
    • pronormoblast
  14. Name this cellImage Upload 7
    • Basophilic normoblast
    • Basophilic erthroblast
    • prorubricyte
  15. Image Upload 8
  16. Name this cell
    Image Upload 9
    • Basophilic normoblast
    • Basophilic erythroblast
    • prorubricyte
  17. Image Upload 10
  18. what is the percentage of polychromatic normoblast in the bone marrow
  19. what is the percentage of orthochromic normoblast in the bone marrow
  20. Name this cell
    Image Upload 11
    • polychromatic erythroblast
    • polychromatic normoblast
    • rubricyte
  21. Name this cell
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  22. Name this Cell
    Image Upload 13
    • polychromatic normoblast
    • polychromatic erythroblast
    • rubricyte
  23. Name this cell
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    • Orthochromic normoblast
    • orthochromic erythroblast
    • metarubricyte
  24. Image Upload 15
  25. Name this cell
    Image Upload 16
    • Orthochromic normoblast
    • Orthochromic Erythrocyte
    • Metarubricyte
  26. what is hypoxia
    lack of oxygen in the tissues
  27. what is erythropoeitin and function and where is it produced
    • Is the major stimulatory cytokine for RBC produced in the kidneys and bone marrow
    • reduces the time needed for reticulocytes in the bone marrow and prevents apoptosis.
    • amount increases when there is a decrease in RBC
  28. why do newborns have higher numbers of RBC than adults
    fetal Hb does not unload oxygen to tissues readily so newborns are slightly hypoxic thus they require more RBCs
  29. What are shift reticulocytes
    early released reticulocytes that are still slightly basophilic due to presence of erythropoeitin
  30. describe the two ways EPO increases circulating RBCs
    • decreasing apoptosis by allowing more precursor cells
    • early release of reticulocytes from the bone marrow
  31. how long does it take for RBC to be released from the bone marrow
    18 days
  32. what are senescent RBC
    cellular aging
  33. what is extravascular hemolysis
    normal hemolysis occuring in the spleen or within the tissues
  34. what is intravascular hemolysis
    hemolysis occuring in within the blood vessels due to mechanical stresses and traumatic environment
  35. where does erythropoeisis occur
    in the erythroid sinuses of the bone marrow
  36. what is fribronectin
    a type of protein that is involved with movement of RBCs toward the sinus
Card Set
Chapter 8: Erythropoeisis and destruction
based on ppt slides