Chapter 8: Erythropoeisis and destruction

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name the stages of erythropoeisis using normoblast
- pronormoblast
- basophilic normoblast
- polychromatic normoblast
- orthochromic normoblast
- reticulocyte
- erythrocyte
what contributes to the blue color of immature erythroblasts

ribosomes
what are the general changes during RBC maturation (3)
- cell size decreases
- blue color decreases
- nucleus condenses and is ejected out
name the rubriblastic maturation stages
- rubriblast
- prorubricyte
- rubricyte
- metarubricyte
- reticulocyte
- erythrocyte
how to ID stem cells as a precursor for RBC
- RBC mature in groups and colonies called burst forming unit -erythroid (BFU-E) or colony forming unit - erythroid (CFU-E)
what type of test distinguishes CFU-E and BFU-E's

flowcytometry. bc cannot be visually distinguished
How to ID RBC maturation
- cell size
- nucleus
- cytoplasm color
Name this cell
- proerythrocyte
- rubriblast
- pronormoblast
name the dark cell
- proerthryocyte
- rubriblast
- pronormoblast
Name this cell
- proerythroblast
- pronormoblast
- rubricyte
Name this cell
- proerythroblast
- pronormoblast
- rubricyte
Name this cell
- proeryrthrocyte
- rubriblast
- pronormoblast
Name this cell
- Basophilic normoblast
- Basophilic erthroblast
- prorubricyte
Name this cell
- Basophilic normoblast
- Basophilic erythroblast
- prorubricyte
what is the percentage of polychromatic normoblast in the bone marrow

10-20%
what is the percentage of orthochromic normoblast in the bone marrow

5-10%
Name this cell
- polychromatic erythroblast
- polychromatic normoblast
- rubricyte
Name this cell
Name this Cell
- polychromatic normoblast
- polychromatic erythroblast
- rubricyte
Name this cell
- Orthochromic normoblast
- orthochromic erythroblast
- metarubricyte
Name this cell
- Orthochromic normoblast
- Orthochromic Erythrocyte
- Metarubricyte
what is hypoxia

lack of oxygen in the tissues
what is erythropoeitin and function and where is it produced
- Is the major stimulatory cytokine for RBC produced in the kidneys and bone marrow
- reduces the time needed for reticulocytes in the bone marrow and prevents apoptosis.
- amount increases when there is a decrease in RBC
why do newborns have higher numbers of RBC than adults

fetal Hb does not unload oxygen to tissues readily so newborns are slightly hypoxic thus they require more RBCs
What are shift reticulocytes

early released reticulocytes that are still slightly basophilic due to presence of erythropoeitin
describe the two ways EPO increases circulating RBCs
- decreasing apoptosis by allowing more precursor cells
- early release of reticulocytes from the bone marrow
how long does it take for RBC to be released from the bone marrow

18 days
what are senescent RBC

cellular aging
what is extravascular hemolysis

normal hemolysis occuring in the spleen or within the tissues
what is intravascular hemolysis

hemolysis occuring in within the blood vessels due to mechanical stresses and traumatic environment
where does erythropoeisis occur

in the erythroid sinuses of the bone marrow
what is fribronectin

a type of protein that is involved with movement of RBCs toward the sinus

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Chapter 8: Erythropoeisis and destruction

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Updated

2016-11-11T01:05:30Z