Cephalosporins

  1. What are first generation cephalosporins used for?
    • - Skin and soft tissue infections owing to S. pyogenes and methicillin-susceptible S. 
      aureus.
    • - Surgical prophylaxis: A single dose of cefazolin just before surgery is the preferred prophylaxis for procedures in which skin flora are the likely pathogens
  2. What is the use of second generation cephalopsorins?
    • - For prophylaxis for intestinal anaerobes as in colorectal surgery. (Cefoxitin)
    • - For ORAL treatment of respiratory tract infections by penicillin resistant S. pneumoniae (e.g. pneumonia and otitis media) SUBOPTIMAL to ampicillin
    • - To cover facultative anaerobes and gram negative organisms (Cefoxitin and Cefotetan) as in:
    •       - Intra-abdominal infections
    •       - PID
    •       - Diabetic foot
  3. Why not use second generation cephalosporins for empirical treatment of pneumonia and meningitis?
    Because of their inferior activity against penicillin-resistan Strept. pneumoniae when compared to Ampicillin and 3rd generation cephalosporins.
Author
Tarek
ID
325446
Card Set
Cephalosporins
Description
Based on Goodman and Gilman's
Updated