Which ACEi used in Stage C HF has the highest max daily dose?
(Capoten); 50 mg TID (150 mg total)
Which ACEi used for Stage C HF has the lowest max daily dose?
trandolapril (Mavik); 4 mg once
True or False. There is benefit from going beyond the target dosing for ACEi's.
False. There is no benefit in going beyond target dosing, and this may leave room to add on other necessary therapy.
What study found that there was NO benefit in the order of starting bisoprolol and enalapril?
CIBIS II
Which two ACEi's are in active form (are NOT pro-drugs; do not have to be activated in the liver)?
captopril (CAPOTEN)
lisinopril (PRINIVIL, ZESTRIL)
What are the contraindications for using ACEi's in HF?
angioedema
anuric renal failure
pregnancy
bilateral artery stenosis
What advantage would the use of carvedilol have over bisoprolol and metoprolol in treating patients with HF?
carvedilol has alpha-1 activity as well as beta-1 and beta-2 activity, where as bisoprolol and metoprolol are selective for beta-1 only. Alpha-1 activity will help to reduce blood pressure.