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what are the different types of monosaccharides?
- glucose: 6 membered ring and 6 carbon atoms (OH is down on C4)
- galactose: 6 membered ring and 6 carbon atoms (OH is up on C4)
- fructose : 5 membered ring and 6 carbon atoms
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what are the different types of disaccharides?
- sucrose = fructose + galactose (in table sugar)
- maltose = glucose + glucose (in beer)
- lactose = glucose + galactose (milk/least sweet)
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what is a glycosidic bond?
the bond that holds 2 glucose units together
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what is hydrolysis?
- hydrolysis is a reaction that slips the molecule in 2
- added H2O
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what are different types of polysaccharides?
- starch : amylopectin and amylose
- glycogen
- celllulose
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what is glycogen?
- storage form of energy in the body
- made of glucose units
- stored in the liver
- short term glucose
- liver cells produce glucose from glycogen to be sent directly to blood
- muscle cells can also produce glucose from glycogen but must use it for themselves
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what are starches?
- storage form of energy in plants
- long chains of glucose
- amylose = unbranched
- amylopectin = branched
- influences cooking characteristics
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what is fibre/cellulose?
provides in them, roots, leaves and skin of plants
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what do the mouth and salivary glands do to starch?
- the salivary glands secrete saliva into the mouth to moisten the food
- the salivary enzyme amylase begins digestion and hydrolyses the starch
- Starch → small polysaccharides and maltose
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what does the stomach do?
the stomach acids intactivate salivary enzymes, halting starch digestion
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what do the small intestine and pancreas do?
- the pancreas produces amylase that is released through the pancreatic duct into the small intestine
- Starch → small polysaccharides and maltose
- then discharges enzymes on the surface of the small intestinal cells hydrolyze the disaccharides into monosaccharides
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- Maltose (by maltase) → glucose + glucose
- Sucrose (by sucrase) → glucose + fructose
- Lactose (by lactase) → glucose + galactose
intestinal cells absorb these monosaccharides
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what does the mouth do to fiber?
it mechanically crushes and breaks down the finer and mixes it with saliva to moisten it fr swallowing
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what does the stomach do to fiber?
fiber is not digested and it delays gastric emptying
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what does the small intestine do to fiber?
- fiber is not digested
- it delays absorption of other nutrients
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what does the large intestine do to fiber?
- fiber passes intact through the digestive tract to the large intestine
- heres how the bacterial enzymes digest finer
- Some fiber (by bacterial enzymes) → short chain fatty acids + gas
- fiber holds water and regulates bowel activity
- fiber binds to water and binds to substances like bile, cholesterol and some minerals and carries them out of the body
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how are monosaccharides absorbed?
- 1. the monosaccharides enter the capillaries of the intestinal villi of the small intestine
- 2. they travel to the liver via the portal vein
- 3. in the liver, galactose and fructose are converted to glucose
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what is lactose intolerance?
- lactose is not properly digested due to the lack of production of lactase on the brush border due to ageing or disease
- NOT an allergy
- undigested lactose can cause some symptoms like nausea, diarrhea, cramps, bloating, flatulence
- it creates an osmotic effect : holds water in the lumen
- solutions: milk with a mean, yogurt, cheese, lactose reduce milk, lactase pills
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what are the functions of glucose in the metabolism?
- precursor for aa
- converted to glycogen for energy storage (short term energy store)
- converted to fat for energy storage (long term energy store)
- oxidized for energy
- prevents ketosis (accumulation of ketone bodies in the blood)
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what is glucose needed for?
- brain cells
- blood cells
- spermatogenesis
- mammary gland
- fetus
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what is hypoglycemia?
↓ blood sugar concentration
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what is hyperglycemia?
↑ blood sugar concentration
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how does our body maintain blood glucose homeostasis when we eat?
- 1. when a person eats, blood glucose ↑
- 2. ↑ blood glucose stimulates the pancreas to release insulin into the blood
- 3. insulin stimulates the uptake of glucose into cells and stage as glycogen in the liver and muscles
- insulin also stimulates the conversion of excess glucose into fat for storage
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how does our body maintain blood glucose homeostasis post absorptive (after fed)?
- 4. as the body uses glucose, blood levels decline ↓
- 5. ↓ blood glucose stimulates the pancreas to release glucagon into the blood stream
- 6. glucagon stimulates liver cells to break down glycogen and release glucose into the blood
- 7. blood glucose begins to rise ↑
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what is type 1 diabetes?
- 10% of cases
- high blood glucose
- destructions of pancreatic cells
- insulin secretion by the B cells of the pancreas is ineffective
- autoimmune, viral
- usually in children
- treatment = exogenous insulin injections, low fat, low GI CHOs and fibre, balance diet and exercise
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what is type 2 diabetes?
- 90% cases
- high blood glucose
- cell are not sensitive to insulin
- "insulin resistance"
- treatment = low fat, low GI CHOs and fibre, weight loss, exercise, diet
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how does it work??
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what is glycemic index
its a method to classify foods according to their potential for raising blood glucose
GI% = glycemic response to 50g of food x100% / glycemic response to 50g of glucose
- lowering the glycemic index of the diet may improve blood lipids and reduce CVD risk
- low glycemic diet can also help with weight management
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what are dental carries?
- the decay of teeth
- begins when acid dissolves the enamel that covers the tooth
- if not repaired, the decay may penetrate the dentin and spread into the pulp of the tooth, accusing inflammation, abscess and possible loss of the tooth
- sugars from foods and breakdown of starches contribute to tooth decay
- bacteria ferment the sugars in the mouth and produce an acid that erodes tooth enamel causing dental carries
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what are some sugar replacers?
- sugar alcohols like xylitol, mannitol, sorbitol
- they're not fermentable and are slowly absorbed
- about 2kcal/g
- "sugar free" dow not mean "no cal"
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what is insoluble dietary fibre?
- from cell walls
- structural
- less fermentable
sources = cellulose, ligin, hemicellulose
- actions in the body =
- ↑ fecal weight and speed fecal passage through colon,
- provide bulk and fullness
- health benefits = alleviate constipation,
- ↓ risks of appendicitis,
- hemorrhoids,
- may help with weight management
foods = fibrous veg, wheat bran
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what is dietary soluble fiber?
- cement
- glue from plants
- more fermentable
sources = pectin, gums, mucilages
- Actions in the body =
- ↓ blood cholesterol by finding to bile,
- slow glucose absorption,
- slow transit of food through upper GI tract, hold moisture in stools,
- softening them,
- yield small fat molecules after fermentation that the colon can use for energy
- Health benefits =
- ↓ list of heart disease
- ↓ risk of diabetes
- foods = additives - carrageenan, guar gum (emulsifier), pectin in jams
- beans, legumes, nuts, fruits, oats, barley
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how does fiber affect work in the small intestine?
- its not digested by out enzymes
- slows abosrption for better glycemic control
- soluble fiber = binds bile acids
- ↓ enterohepatic circulation
- ↓ fat, cholesterol and fat soluble vitamin absorption
- ↓ cholesterol levels
- insoluble fiber = binds cations
- phytates ↓ Fe, Ca, Zn absorption
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enetrohepatic circulation
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what are the action of finer in the colon?
- ↑ GI motility, speeds up transit
- attracts water, bulk
- ↓ constipation, diverticular disease, haemorrhoids
- fermented by intestinal bacteria
- gas - CH4, H2, CO2
- short chat FAs
- energy for colonocytes
- binds bile acids and toxicants - protects colon
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what are the dietary recommendations for finer?
current intake = 20-25g/d
- AI for finer base don energy intake:
- 38g/day for men
- 25g/d for women
NO UL FOR FIBER
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what are the health effects of low GI foods and fiber ?
- 1. weight control
- foods tend to be ↓ in fat and ↑ satiety and bulk
- 2. heart disease
- ↓ in saturated fat, ↑ in phytochemical
- ↓ cholesterol
- 3. cancer
- ↓ colon cancer risk, ↓ pH phytochemical, vitamins
- 4. diabetes
- glycemic control
- weight control
5. GI health
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