Antibiotics and Mechanisms of Action

Inhibit cell biosynthesis

Inhibit bacterial topoisomerase

Increase permeability of membrane causing leakage

Inhibit folic acid synthesis, which is in turn required for synthesis of nucleotides and methionine (bacteria make their methionine and humans ingest theirs so little effect on human protein synthesis)

Inhibits ile-tRNA synthetase

Binds to the isolated 50S subunit to block initiation step of translation

Blocks binding of aa-tRNA to the A site on 30S subunit

Binds 50S P site and inhibits peptide formation

Binds to 20S to cause misreading of the genetic code

Binds 50S to block the translocation process

Binds to 50S P site to prevent peptide bond formation

Binds to 50S P site blocks entrance to tunnel causing release of incomplete peptides

Binds to 50S A stie and is incorporated into a growing chain leading to early termination