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pharm ch 18
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receptor sites for the catecholamines norepinephrine and epinephrine
adrenergic receptor
where are alpha1 receptor located?
postsynaptic effector cells
where are alpha2 receptor located?
presynaptic nerve terminals
they control release of neurotransmitter
alpha 1 and 2
what is the predominant alpha-adrenergic agonist response?
vasoconstriction and CNS stimulation
where are beta-adrenergic receptor located?
they are all located on postsynaptic effector cells
what are beta-adrenergic agonist response result?
results in bronchial, GI, uterine smooth muscle relaxation; glycogenolysis and cardiac stimulation
2 enzyme that metabolize catecholamines
monoamine oxidase (MAO) and catechol orthomethyltransferase (COMT)
enzyme that breaks down catecholamines that are i nerve ending
MAO
enzyme that breaks down catecholamines that are outside the nerve ending at the synaptic cleft
COMT
adrenergic synthetic substances
dobutamine
phenylephrine
noncathecholamine adrenergic drugs. they have longer duration of action
phenylpherine
metaproterenol
albuterol
used to support the cardiovascular system during cardiac failure or shock
vasoactive symphathomimetics, vasoconstrictive drugs (vasopressive), inotropes or cardioselective sympathomimetics
unwanted CNS effects of the alpha-adrenergoc drugs
headache
restlessness
excitement
insomia
euphoria
possible cardiovascular adverse effect if the alpha-adrenergic drugs
chest pain
vasoconstriction
HTN
reflexive bradycardia
palpitations and dysrhythmias
beta-adrenergic drugs can adversely stimulate the CNS causing:
tremors
HA
nervousness
dizziness
increase heart rate
sweating
muscle cramps
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Author
Anonymous
ID
323792
Card Set
pharm ch 18
Description
adrenergic drugs
Updated
2016-09-30T04:17:28Z
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