pharm ch 18

  1. receptor sites for the catecholamines norepinephrine and epinephrine
    adrenergic receptor
  2. where are alpha1 receptor located?
    postsynaptic effector cells
  3. where are alpha2 receptor located?
    presynaptic nerve terminals
  4. they control release of neurotransmitter
    alpha 1 and 2
  5. what is the predominant alpha-adrenergic agonist response?
    vasoconstriction and CNS stimulation
  6. where are beta-adrenergic receptor located?
    they are all located on postsynaptic effector cells
  7. what are beta-adrenergic agonist response result?
    results in bronchial, GI, uterine smooth muscle relaxation; glycogenolysis and cardiac stimulation
  8. 2 enzyme that metabolize catecholamines
    monoamine oxidase (MAO) and catechol orthomethyltransferase (COMT)
  9. enzyme that breaks down catecholamines that are i nerve ending
  10. enzyme that breaks down catecholamines that are outside the nerve ending at the synaptic cleft
  11. adrenergic synthetic substances
    • dobutamine
    • phenylephrine
  12. noncathecholamine adrenergic drugs. they have longer duration of action
    • phenylpherine
    • metaproterenol
    • albuterol
  13. used to support the cardiovascular system during cardiac failure or shock
    vasoactive symphathomimetics, vasoconstrictive drugs (vasopressive), inotropes or cardioselective sympathomimetics
  14. unwanted CNS effects of the alpha-adrenergoc drugs
    • headache
    • restlessness
    • excitement
    • insomia
    • euphoria
  15. possible cardiovascular adverse effect if the alpha-adrenergic drugs
    • chest pain
    • vasoconstriction
    • HTN
    • reflexive bradycardia
    • palpitations and dysrhythmias
  16. beta-adrenergic drugs can adversely stimulate the CNS causing:
    • tremors
    • HA
    • nervousness
    • dizziness
    • increase heart rate
    • sweating
    • muscle cramps
Card Set
pharm ch 18
adrenergic drugs