pharm ch 18

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receptor sites for the catecholamines norepinephrine and epinephrine

adrenergic receptor
where are alpha1 receptor located?

postsynaptic effector cells
where are alpha2 receptor located?

presynaptic nerve terminals
they control release of neurotransmitter

alpha 1 and 2
what is the predominant alpha-adrenergic agonist response?

vasoconstriction and CNS stimulation
where are beta-adrenergic receptor located?

they are all located on postsynaptic effector cells
what are beta-adrenergic agonist response result?

results in bronchial, GI, uterine smooth muscle relaxation; glycogenolysis and cardiac stimulation
2 enzyme that metabolize catecholamines

monoamine oxidase (MAO) and catechol orthomethyltransferase (COMT)
enzyme that breaks down catecholamines that are i nerve ending

MAO
enzyme that breaks down catecholamines that are outside the nerve ending at the synaptic cleft

COMT
adrenergic synthetic substances
- dobutamine
- phenylephrine
noncathecholamine adrenergic drugs. they have longer duration of action
- phenylpherine
- metaproterenol
- albuterol
used to support the cardiovascular system during cardiac failure or shock

vasoactive symphathomimetics, vasoconstrictive drugs (vasopressive), inotropes or cardioselective sympathomimetics
unwanted CNS effects of the alpha-adrenergoc drugs
- headache
- restlessness
- excitement
- insomia
- euphoria
possible cardiovascular adverse effect if the alpha-adrenergic drugs
- chest pain
- vasoconstriction
- HTN
- reflexive bradycardia
- palpitations and dysrhythmias
beta-adrenergic drugs can adversely stimulate the CNS causing:
- tremors
- HA
- nervousness
- dizziness
- increase heart rate
- sweating
- muscle cramps

Author

Anonymous

323792

Card Set

pharm ch 18

Description

adrenergic drugs

Updated

2016-09-30T04:17:28Z

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