Cardio Pharmacology

Enhance Mycocardial contractility by stimulating adrenergic receptors

Special Considerations:

Continuous monitoring of ECG, BP, HR, peripheral circulation

• Dopamine (Intropin)
• Dobutamine (Dobutrex)
• Epinephrine (Adrenaline)
• Norepinephrine (Levophed)
• Isoproterinol (Isuprel)

• Inotropic Drug
• Sympathomemetic

3mcg/kg/min - used for kidney perfusion

3-10 mcg dose - B1 stimulation: improves heart contractility and CO

>10mcg/kg/min-Alpha stimulation - vasoconstriction

• Inotropic Drug
• Sympathomemtic

Affects B1 receptors of heart - increased contractility without increases in BP from vasoconstriction

• Inotropic Drug
• Sympathomemetics

• Low doses stimulate Beta receptors:
• Increase HR, Contractility, vasodilation

• High doses (>2mg/min) stimulate alpha receptors
• Vasoconstricion

• Inotropic Drug
• Sympathomemetics

• Stimulates Beta 1 (heart) and
• Higher doses stimulate Alpha receptors (vascular)

• Inotropic Drug
• Sympathomemetic

NEVER GIVE IV PUSH - only give IV Drip

Pure Beta receptor stimulant with no alpha effects

• Limited usefulness do to dysrhythmia issues
• Profound increases in HR, Conduction, and Contractility.
• Produces vasodilation of pulm arteries and bronchodilation.