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General anesthesia is characterized by some degree of... (5)
hypnosis, muscle relaxation (akinesia), analgesia, amnesia, hypo-reflexia (autonomic response)
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Describe the unitary theory of anesthetic action.
general anesthetics are lipid soluble and distort the neuronal lipid bilayer by distorting the membrane-bound protein channels in the lipid bilayer
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Anesthetic potency is related to _________.
lipid solubility
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What is the site of action of general anesthetics? (3)
- disrupt of ascending neural transmission within the brainstem reticular formation and thalamus
- depression of cerebral cortical neurons
- spinal cord site of action for muscle relaxation and autonomic reflex suppression
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Describe how size and weight effects an animal's anesthetic dosage.
anesthetic dosage should be calculated based on an animals ideal weight b/c the blood flow to fat is minimal and has little effect on the action of anesthetic (it's easy to overdose an obese animal)
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What are the classes of the physical status classification scheme? (6)
- Class I: normal, healthy patient
- Class II: mild systemic dz, slight risk (neonate, geriatric, mild dehydration, mild anemia, obese)
- Class III: severe systemic dz that is not incapacitating (regulated diabetic, early CKD)
- Class IV: incapacitating dz that is life-threatening (shock, GDV, etc)
- Class V: moribund patient not expected to live 24 hr (organ donor, organ failure)
- Class E: emergency, immediate anesthesia required (combined with a #)
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