CH 52

  1. Anti-infectives for UTI (drugs)
    • Cinoxacin- interferes with gram - bacteria 
    • Norfloxacin- eff against more gram - bacteria
    • Fosfomycin- only one dose 
    • Nalidixic acid- older not as eff for many gram -
    • Nitrofurantoin- older drug, very short 1/2 life
  2. Drugs that acidify urine
    • methenamine-can be used for children 
    • Methylene Blue- widely distributed in tissues
  3. action of anti-infectives
    • destroy bacteria in UT
    • through Abx or acidifying
  4. indications of anti-infectives
    • chronic UTI
    • acute cystitis/pyelonephritis 
    • prophylaxis w/abnormalities 
    • residual urine disorders
  5. caution anti-infectives
    renal dysfunction
  6. AE of anti-infectives
    bladder irritation, dysuria, pruitus, urticaria
  7. Antispamstics actions
    relaxes detrusor muscles, blocks spasms
  8. Name of antispasmatic
  9. indications of antispasmatics
    bladder spasm and dysuria
  10. contraindications of antispasmatics
    • pyloric/duodenal obstruction 
    • recent surgery
    • obstructive UT problems
    • glaucoma, MG, acute hemorrhage
  11. caution with antispasmatics
    renal/hepatic dysfunction
  12. Drug interactions with antispasmatics
    • Pheothiazines 
    • Haloperidol
  13. UT analgesics name
  14. UT analgesics actions
    when med is excreted in urine it exerts direct topical analgesic effect on the urinary mucosa
  15. UT analgesic indications
    relief s/s of UT irritation, infection, trauma, surgery
  16. Contraindication of UT analgesic
    renal dysfunction
  17. AE of UT analgesics
    GI upset, rash, reddish-orange urine, renal/hepatic toxicity
  18. Drug interaction with UT analgesics
    antibacterial agents
  19. Drug name for Bladder protectants
    Pentosan Polysulfate Sodium
  20. action of Bladder protectant drugs
    • heparin-like drug that has anticoag effects
    • adheres to bladder wall and acts as a bufer to control cell permeability 
    • prevents irritating solutions from reaching bladder walls
  21. Indications of Bladder protectant drugs
    interstitial cystitis
  22. Contra of Badder protectant drugs
    • bleeding 
    • heparin induced thrombocytopenia
  23. caution with Bladder protectant drugs
    hepatic/splenic dysfunction
  24. AE of bladder protectant drugs
    • bleeding
    • alopecia, GI disturbances
  25. Drug interactions with bladder protectant drugs
    Anticoags, NSAIDS, aspirin
  26. Name of BPH drug
    tamsulosin (Flomax)
  27. action of BPH drug
    blocks postsynaptic AA receptors=dilation of arteries/veins
  28. caution with BPH drugs
    hepatic/renal dysfunction
  29. AE of BPH drugs
    postural dizziness, lethargy, tachycardia, hypoTN, GI upset, decreased libido
  30. Drug interactions of BPH
Card Set
CH 52
CH 52