CH 52

  1. Anti-infectives for UTI (drugs)
    • Cinoxacin- interferes with gram - bacteria 
    • Norfloxacin- eff against more gram - bacteria
    • Fosfomycin- only one dose 
    • Nalidixic acid- older not as eff for many gram -
    • Nitrofurantoin- older drug, very short 1/2 life
  2. Drugs that acidify urine
    • methenamine-can be used for children 
    • Methylene Blue- widely distributed in tissues
  3. action of anti-infectives
    • destroy bacteria in UT
    • through Abx or acidifying
  4. indications of anti-infectives
    • chronic UTI
    • acute cystitis/pyelonephritis 
    • prophylaxis w/abnormalities 
    • residual urine disorders
  5. caution anti-infectives
    renal dysfunction
  6. AE of anti-infectives
    bladder irritation, dysuria, pruitus, urticaria
  7. Antispamstics actions
    relaxes detrusor muscles, blocks spasms
  8. Name of antispasmatic
    Oxybutynin
  9. indications of antispasmatics
    bladder spasm and dysuria
  10. contraindications of antispasmatics
    • pyloric/duodenal obstruction 
    • recent surgery
    • obstructive UT problems
    • glaucoma, MG, acute hemorrhage
  11. caution with antispasmatics
    renal/hepatic dysfunction
  12. Drug interactions with antispasmatics
    • Pheothiazines 
    • Haloperidol
  13. UT analgesics name
    Phenazopyridine
  14. UT analgesics actions
    when med is excreted in urine it exerts direct topical analgesic effect on the urinary mucosa
  15. UT analgesic indications
    relief s/s of UT irritation, infection, trauma, surgery
  16. Contraindication of UT analgesic
    renal dysfunction
  17. AE of UT analgesics
    GI upset, rash, reddish-orange urine, renal/hepatic toxicity
  18. Drug interaction with UT analgesics
    antibacterial agents
  19. Drug name for Bladder protectants
    Pentosan Polysulfate Sodium
  20. action of Bladder protectant drugs
    • heparin-like drug that has anticoag effects
    • adheres to bladder wall and acts as a bufer to control cell permeability 
    • prevents irritating solutions from reaching bladder walls
  21. Indications of Bladder protectant drugs
    interstitial cystitis
  22. Contra of Badder protectant drugs
    • bleeding 
    • heparin induced thrombocytopenia
  23. caution with Bladder protectant drugs
    hepatic/splenic dysfunction
  24. AE of bladder protectant drugs
    • bleeding
    • alopecia, GI disturbances
  25. Drug interactions with bladder protectant drugs
    Anticoags, NSAIDS, aspirin
  26. Name of BPH drug
    tamsulosin (Flomax)
  27. action of BPH drug
    blocks postsynaptic AA receptors=dilation of arteries/veins
  28. caution with BPH drugs
    hepatic/renal dysfunction
  29. AE of BPH drugs
    postural dizziness, lethargy, tachycardia, hypoTN, GI upset, decreased libido
  30. Drug interactions of BPH
    Theophylline
Author
maria_mm_10
ID
322110
Card Set
CH 52
Description
CH 52
Updated