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Bioenergetics
the study of the various types of energy transformations that occur in living organisms
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energy
- the capacity to do work, or the capacity to change or move something
- a) electrical energy can be transduced to mechanical energy when we plug in a clock
- b) chemical energy is converted to mechanical energy when heat is released during muscle contraction
- c) fireflies and luminous fish are able to convert chemical energy back to light
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The First Law of Thermodynamics
energy can neither be created nor destroyed, it can only change forms
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transduction
- the change from one form of energy to another
- *photosynthesis is the most important energy ~ in the biological world; sunlight to chemical energy
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The Second Law of Thermodynamics
expresses the concept that events in the universe have direction; they tend to proceed "downhill" from a state of higher energy to a state of lower energy
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Free Energy
(delta) G - the maximum amount of energy that can be passed on for use in another process
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exergonic
- processes that can occur spontaneously, that is, processes that have a negative delta G
- favors the formation of products
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endergonic
- processes that are thermodynamically unfavorable, that is, they have a positive delta G (non spontaneous, you must put energy in)
- favors the formation of reactants
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enzymes
- are catalyst that speed up chemical reactions (accelerate bond-breaking/forming processes)
- are almost always proteins
- may be conjugated with nonprotein components
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cofactors
- inorganic enzyme conjugates (nonprotein components)
- most are metals - Zinc is important, also Iron, Magnesium
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coenzymes
organic enzyme conjugates; Vitamins
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Properties of Enzymes
- Are present in cells in small amounts
- Are not permanently altered during the course of a reaction (can participate repeatedly)
- Cannot affect the thermodynamics of reactions, only the rates
- Are highly specific for their particular reactants called substratesProduce only appropriate metabolic products
- Can be regulated to meet the needs of a cell
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transition state
- reactants that are at the crest of the energy hump and ready to be converted to products are said to be at the ~
- few substrate molecules can reach this without an enzyme or catalyst
- compounds that resemble the ~ tend to be very effective inhibitors (they can bind tightly to the catalytic region of the enzyme
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