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CLSBB01 - Genetics for Blood Bankers
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# chromosomes
22 pairs autosomes
1 pair sex
Mendel's first law
Independent segregation: each gamete has equal probability of receiving chromosome
Mendel's second law
Independent assortment: genes determining traits are inhereted independently
locus, allele, amorph
locus
: specific location of gene on chromosome
allele
: specific "version" of gene
amorph
: null gene
Using inheritence traits - key
square = male
circle = female
dark = affected
clear = unaffected
Haplotype
Linkage between genes that causes them to get inherited together (typically)
*note - linkage is measured by distance between loci (>50% chance of crossing over = no linkage)
public vs private genes
public
: high frequency
private
: low frequency
Direct exclusion vs indirect exclusion
Direct
: child possesses a trait NOT FOUND IN EITHER PARENT
Indirect
: child lacks a trait the they father "should" have transmitted (was homozygous for)
What is a paternity index?
AKA Probability of exclusion
If a father cannot be excluded from paternity his probability can be calculated by comparison with a "random man" of the same ethnic group
**Modern uses DNA testing
Hardy-Weinbrg Principle
p
2
+ pq + q
2
= 1 p + q = 1
Author
victimsofadown
ID
320971
Card Set
CLSBB01 - Genetics for Blood Bankers
Description
CLSBB01 - Genetics for Blood Bankers
Updated
2016-06-12T22:01:40Z
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