CLSBB01 - Genetics for Blood Bankers

# chromosomes
- 22 pairs autosomes
- 1 pair sex
Mendel's first law

Independent segregation: each gamete has equal probability of receiving chromosome
Mendel's second law

Independent assortment: genes determining traits are inhereted independently
locus, allele, amorph
- locus: specific location of gene on chromosome
- allele: specific "version" of gene
- amorph: null gene
Using inheritence traits - key
- square = male
- circle = female
- dark = affected
- clear = unaffected
Haplotype
- Linkage between genes that causes them to get inherited together (typically)
- *note - linkage is measured by distance between loci (>50% chance of crossing over = no linkage)
public vs private genes
- public: high frequency
- private: low frequency
Direct exclusion vs indirect exclusion
- Direct: child possesses a trait NOT FOUND IN EITHER PARENT
- Indirect: child lacks a trait the they father "should" have transmitted (was homozygous for)
What is a paternity index?
- AKA Probability of exclusion
- If a father cannot be excluded from paternity his probability can be calculated by comparison with a "random man" of the same ethnic group
- **Modern uses DNA testing
Hardy-Weinbrg Principle

p² + pq + q² = 1 p + q = 1

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victimsofadown

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Card Set

CLSBB01 - Genetics for Blood Bankers

Description

CLSBB01 - Genetics for Blood Bankers

Updated

2016-06-12T22:01:40Z

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