CLSBB01 - Genetics for Blood Bankers

  1. # chromosomes
    • 22 pairs autosomes
    • 1 pair sex
  2. Mendel's first law
    Independent segregation: each gamete has equal probability of receiving chromosome
  3. Mendel's second law
    Independent assortment: genes determining traits are inhereted independently
  4. locus, allele, amorph
    • locus: specific location of gene on chromosome
    • allele: specific "version" of gene
    • amorph: null gene
  5. Using inheritence traits - key
    • square = male
    • circle = female
    • dark = affected
    • clear = unaffected
  6. Haplotype
    • Linkage between genes that causes them to get inherited together (typically)
    • *note - linkage is measured by distance between loci (>50% chance of crossing over = no linkage)
  7. public vs private genes
    • public: high frequency
    • private: low frequency
  8. Direct exclusion vs indirect exclusion
    • Direct: child possesses a trait NOT FOUND IN EITHER PARENT
    • Indirect: child lacks a trait the they father "should" have transmitted (was homozygous for)
  9. What is a paternity index?
    • AKA Probability of exclusion
    • If a father cannot be excluded from paternity his probability can be calculated by comparison with a "random man" of the same ethnic group
    • **Modern uses DNA testing
  10. Hardy-Weinbrg Principle
    p2 + pq + q2 = 1     p + q = 1
Author
victimsofadown
ID
320971
Card Set
CLSBB01 - Genetics for Blood Bankers
Description
CLSBB01 - Genetics for Blood Bankers
Updated