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Cytokines

  1. IL-8
    • Chemotaxis (low concentration)
    • Activation of PMNs (high concentration)
  2. TNF-a
    • Inflammation
    • Promotes IL-1 production
    • Stimulates endothelial cells to express adhesion factors
    • Promote migration of Neutrophils to site
  3. IL-1
    • Inflammation
    • Activates T-cells
    • Acts like TNF-a
  4. IFN-g
    • Inflammation
    • Anti-viral
    • Promotes Th1; inhibits Th2
    • Stimulates expression of MHC I/II
    • Stimulates B-cell class switching
  5. IL-10
    • Immunosupression
    • Inihibits MHC II on macrophages
    • Inhibits IL-12/TNF production
  6. IL-2
    Proliferation and differentiation of immune cells
  7. TGF-b
    Inhibition of proliferation
  8. IL-12
    • Induces cell-mediated immunity
    • Increases ability of NK and CTLs
  9. IL-6
    Proliferation of plasma cells
  10. IL-5
    • Growth and differentiation of eosinophils
    • B-cell differentiation
    • IgA production
  11. IL-4
    • Development of Th-2
    • B-cell class switch to IgE
  12. Th-1 (cell mediated)
    • IL-2
    • IFN-g
    • TNF-b
  13. Th-2 (humoral)
    • IL-4
    • IL-5
    • IL-10
  14. IL-12 -> Th-1
    IFN-g -> intracellular pathogens
  15. IL-4 -> Th-2
    IL-4 -> extracellular pathogens
  16. TGF-b + IL-6/IL-21 -> Th-17
    IL-17/IL-22 -> extracellular bacteria, inflammation
  17. TGF-b - IL-6 -> Treg
    IL-10 -> immunosuppresion, anti-inflammatory
Author
duncamunk
ID
32094
Card Set
Cytokines
Description
Cytokines for first immuno test
Updated

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