1. What is the source and function of IL-1?
    source: phagocytes, marcophages, and monocytes

    Function: Activator of T-cells, acts like TNF cells, controls inflammatory response, increases surface adhesion to endothelial cells
  2. What is the source and function of IL-2?
    Source: T-cells after Ag binding

    Function: promotes proliferation and differentiation of immune cells. Promotes apoptosis of Ag-activated T-cells to control immune system
  3. What is the source and function of IL-4?
    Source: T-Helper 2 cells, mast cells, and basophils

    • Function: B-cell isotype switching to IgE, Development of TH-2 cells for naive CD4+ T-cells,
    • Autocrine growth factor for TH-2 cells, Inhibits IFN gamma from activating macrophages
  4. What is the source and function of IL-5?
    Source: TH-2 cells and Mast cells

    Function: growth and differentiation of eosinophils (parasitic infection), B-cell differentiation, production of IgA
  5. What is the source and function of IL-6?
    Source: Macrophages, endothelial cells, T-cells

    Functions: proliferation of plasma cells ->Ab, synthesis of proteins in liver that are important for inflammation
  6. What is the source and function of IL-10?

    (hint only one source)
    Source: Th-2 cells

    Function: Inhibits expression of MHC II on macrophages, inhibits macrophages from making IL-12 and TNF, inhibits expression of co-stimulators
  7. What is the source and function of IL-12?
    Source: mononuclear phagocytes, dendritic cells

    Function: Secretion of IFN gamma by NK cells and T-cells, Inc. catalytic activity of NK cells and cytotoxic CD8+ T cells, Differentiation of CD4+ (TH-1) T cells, Mediates early innate immunity and induces cell mediated immunity
  8. What is the source and function of TNF?
    Source: mononuclear phagocytes

    Function: induction of IL-1 production by macrophages, apoptosis of some cell types, mediates acute inflammatory response to microbes, recruitment and activation of neutrophils and monocytes to sites of infection, stimulates endothelial cells to express adhesion molecules and chemokines
  9. What is the function Chemokines?
    stimulate leukocytes movement, regulates migration of lymphocytes from blood to tissues (chemotactic cytokines), important to immune response to local infections
  10. What is the source and function of Type 1 Interferons: IFN- alpha (leukocyte IFN), IFN-beta ( fibroblast IFN)?

    (hint the source of IFN alpha is different from IFN beta)
    Source: IFN alpha made by mononuclear phagocytes, IFN beta made by many cells mostly fibroblasts

    • Function:
    • IFN-α-family of 20 sx related polypeptides, IFN-β-single protein, Inhibit viral replication, Stimulate development of TH-1, Increase expression of MHC-1, Innate response to viral infections, Cell-mediated response to microbes
  11. What is the source and Function of IFN gamma?
    Source: T-cells and NK cells

    Function: Principle macrophages activating enzyme, promotes TH-1 differentiation, Inhibit TH-2 differentiation, promotes B-cell isotype switching, stimulate expression of MHC-1 MHC-2 and co-stimulators
  12. What is the source and function of Transforming Growth factor TGF- beta?
    Source: T-cells, mononuclear phagocytes

    Function: Inhibit proliferation and differentiation of T-cells, Inhibit activation of macrophages
  13. What is the source and function of Lymphotoxin? (LT)
    source: T lymphocytes

    Function: 30% homologous to TNF, activates endothelial cells, activates neutrophils
  14. IgG protective function?
    antiviral, antibacterial, antitoxin, agglutinin

    other facts: crosses placenta (passive immunity for newborns), activates complement
  15. Serum IgA
    no known bio function, it has a dimer structure
  16. IgM
    antiviral, antibacterial, GOOD antiglutinin, first Ig to respond, doesn't leave blood stream

    pentameric structure
  17. IgD
    • no known protective function
    • it helps with maturation of B cells
  18. IgE
    in high numbers during parasitic infection

    mediates type 1 hypersensitivity, binds to mast cells and basophils
  19. sIgA (secretory)
    antiviral antibacterial and aggultinin

    major Ig in secretions, protect mucosal from infections
  20. What Ig has no fuction in serum?
  21. What Ig has a monomer on the surface of Bcell and is pentamer serum?
  22. Which Ig is involved with type 1 hypersensitivity?
  23. What Ig is involved in the immune response to parasites?
  24. What Ig appears in tears?
  25. What Ig is the predominant antibody in serum in the secondary immune response?
  26. What Ig has four subclasses of heavy chains?
  27. Which Ig has two subclasses of Heavy chains?
  28. What Ig is the best agglutinin?
  29. Which Ig is bound to surface of mast cells?
  30. IL-1:

  31. IL-12:
    a. stimulates the production of inteferon-γ by NK cells and T cells
    b. is primarily secreted by activated mononuclear phagocytes and dendritic cells
    c. enhances the cytolytic function of activated NK cells and T cytotoxic cells
    d. all of the above
    e. a and b only
  32. 62. IL-4:
    a. is produced by TH2 cells, activated mast cells and basophils
    b. stimulates B cell isotype switching to IgG
    c. enhances surface adhesion molecule expression on endothelial cells
    d. all of the above
    e. a and b only
  33. Type I interferons:
    a. inhibit viral infection
    b. increase expression of class I MHC molecules
    c. enhance surface adhesion molecule expression on endothelial cells
    d. all of the above
    e. a and b only
  34. Secretory IgA antibodies
    :a. cross the placenta when coupled to J chain
    b. bind C1 in activation of the classical complement activation pathway
    c. are the predominant immunoglobulin in serum
    d. mainly exist as monomers
    e. are the predominant immunoglobulin in saliva
  35. the first immunoglobulin synthesized in response to an initial exposure to antigen
  36. most important in protecting a newborn from common bacteria
  37. important in protecting against parasitic infections
  38. most abundant immunoglobulin in serum
  39. can bind to the largest number of epitopes
  40. the major immunoglobulin produced in the memory response
  41. role in B cell maturation, but no known protective function
Card Set
IL, Ig etc