-
Cyclosporine
Immunosuppressant agent for organ transplants that comes in a liquid suspension used in tx of OLP in diabetic pts
-
Mycostatin
- example: Nystatin
- -Topical antifungal
- -Little side effects
- -Use short term (high sugar content)
- -oral suspension (can swallow) no sx effect
-
Imidazoles
- -example: clotrimazole, miconazole, keteoconazole (kete mostly used on skin, sx vers has a lot of side effects avoid)
- -Topical antifungal
- -MORE potent (use this for more severe cases)
-
Amphotericin B
- -IV and PO
- -SEVERE systemic
- -alternative to azoles
- -side effect nephrotoxicity
- -used for other fungal infection (aspergillosis)
-
Fluconazole
- -PO or IV antifungal
- -systemic
- -very potent
- -under traizole category
-
Itraconazole
- -same as fluconazole
- -oral suspension for topical and systemic effects
- -under triazole category
- -STRONG inhibitor of cytochrome P450 enzyme
-
Glucocorticoid (list)
- example: Prednisone, dexamethasone
- -
-
Immunophilin (list)
- -example: cycosporine, tacrolimus, sirolimus
- -organ transplant
- -side effect: nephrotoxicity
-
cyclosporine
- -immunophilin
- -oral solution
- -eye drops
-
cytotoxic drugs
- used in cancer tx
- causes BM suppression
- examples: Azathioprine, mycophenolate, methotrexate
-
Methotrexate
- folic acid antagonist
- used in rheumatoid arthritis
-
Thalidomide
good for behcets syndrome, apthous ulcers in HIV infections due to systemic problems
-
Immune modulators (list)
example: thalidomide, biological agents
-
DMARDs
- example: gold, sulfasalazine, dapsone
- DMARDs are 3rd line therapy when all else failed
-
Dapsone
Abx used in tx of systemic RAS
-
Anesthetic agents for tx of apthous ulcers
- OTC benzocaine
- Viscous lidocaine (only lasts 5 min)
- compounded anesthetic (last 30 min-1hr)
-
Amlexanox 5% paste
- inhibits histamine release
- limits duration of RAS
- use this instead of CREST toothpaste
-
List of topical steroids
- Clobetasol
- Fluocinonide
- Betamethasone
-
Betamethasone
- topical steroid
- intermediate strength
-
Fluocinonide
- topical steroid
- POTENT
- Most commonly used potent topical corticosteroid for tx of OLP
-
Clobetasol
- topical steroid
- ULTRA potent
-
Betamethasone
- syrup form
- intermediate potency
- easy to access areas that cannot be applied topically
-
Dexamethasone
- high potency
- elixer/also used as injection
- Systemic agent that comes as liquid suspension, can be used both systemically and topically in tx of MMP
-
Prednisolone
- syrup
- ULTRA high potency
- best used for systemic use
-
Some corticosteroids are readily absorbed through ulcerated and inflamed surfaces. Those absorbed systemically can cause adrenal suppression if used more than _______. Continuous use reduces their effectiveness, withdrawal _________ restores action. Continuous use may lead to ___________ infections
-
RAS + associated systemic conditions
- Behcet
- GI absorption problems (Crohns UC)
- Cyclic neutropenia
-
Systemic therapies in RAS
- Prednisone
- Thalidomide
- Etanercept
- Dapsone
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