Inhibits viral replication
Innate response to viral infections
Stimulates development of Th1
Increases expressin of MHC Class 1
Type 1 Interferon
-B cell differentiation
-IgA
-Growth and differentiation of eosinophils
IL-5
-Inhibits proliferation and differentiation of T cells
-Inhibits activation of macrophages
TGF-Beta
-Promotes proliferation and differentiation of Immune cells
-Apoptosis of Ag-activated T cells
IL-2
-B-cell isotype switching to IgE
-Inhibits IFN-Gamma from activating macrophages
-Development of TH-2 cells
IL-4
-Proliferation of plasma cells --> Ab
IL-6
-Acts like TNF
-Activates T cells
-Inflammation
IL-1
-Induction of IL-1 production by macrophages
-Apoptosis of some cell types
-Recruitment and activation of neutrophils and monocytes to sites of infection
-Stimulates endothelial cells to express adhesion molecules and chemokines
-Inhibit MHC Class II on macrophages
-Inhibits macrophages from making IL-12 and TNF
-Inhibits co-stimulators
-Immunosuppression (anti-inflammatory)
IL-10
-Secretion of IFN-Gamma by NK and T cells
-Increase NK and CD8 T cells
-Differentiation of CD4 (TH1) T cells
-Mediates early innate immunity
-Induces cell-mediated immunity
IL-12
30% homologous to TNF
-Activates endothelial cells and neutrophils
Lymphotoxin (LT)
-Enhances immunogenecity
-Required for vaccines
Adjuvant
Ag that is not an immunogen. But if attached to an immunogenic molecule makes it an immunogen.
-An Ag that requires a carrier molecule to stimulate and immune response.