Thyroid hormone disorder pharm

  1. propylthiouracil and methimazole
    • thiouracil drug - inhibits T4 synthesis
    • inhibits peroxidase enzyme which oxidizes iodide to iodine
    • adverse effects: serious liver injury and agranulocytosis (deficiency in neutrophils due to bone marrow damage, congestive heart failure, pulmonary edema
    • propylthiouracil also acts on peripheral tissue to inhibit monodeiodinase (catalyzes conversion of T4 to T3)
  2. thiocyanate and perchlorate
    • competitive inhibitors of the sodium-iodide symport protein
    • block "iodide trapping" by follicular cells
    • used alone or in combination with other drugs that block thyroid hormone synthesis
  3. levothyroxine sodium (Synthroid)
    synthetic T4 used in hormone replacement therapy
Author
jboi
ID
320248
Card Set
Thyroid hormone disorder pharm
Description
MOHD3 lecture 101
Updated