Pain Wang

  1. The pro-seizure chemical laudanosine is a metabolite of which of the following drugs?



    C) Atracurium
  2. Non-depolarizing muscle relaxant mivacurium may increase histamine release. The concern(s) associated with this action is/are: (select all that apply)




    • D) Bronchospasm
    • E) Hypotension
  3. High dose aspirin reduces the formation of prostaglandins by inhibiting



    B) Cyclooxygenase 2 (COX2)
  4. Which of the following is a correct rank order regarding the relative risks of GI complications of these NSAIDs (“> ” means greater risk than)?




    C) Piroxicam > Indomethacin > Naproxen > Aspirin
  5. The therapeutic effect of sumatriptan on migraine headaches is mediated by two primary mechanisms. They are (Select all that apply):
    A) Inhibition of vasodilating peptide release
    B) Direct constriction of small arteries
    C) Relaxation of the intracranial cerebral blood vessels
    D) Increase in the production of prostaglandins
    • A) Inhibition of vasodilating peptide release
    • B) Direct constriction of small arteries
  6. Which of the following are paired incorrectly?



    A) Thiopental / activate GABA-B receptors
  7. Local anesthetic agent lidocaine blocks which of the following ion channels?




    A) Sodium
  8. Which of the following is a mixed agonist-antagonist of opioid receptors?




    C) Buprenorphine
  9. Which of the following is the wanted effect of a general anesthetic?




    D) Unconsciousness and analgesia
  10. Based on the definition of MAC, the MAC number of a general anesthetic is similar to which of the following measurements?   



    B) EC50
  11. The blood:gas partition coefficients for nitrous oxide and isoflurane are 0.47 and 1.4, respectively.  The solubility of these two agent in blood is:



    B) Isoflurance > Nitrous oxide
  12. Which of the following may not be a target of general anesthetics?




    A) Nerve trunks of the extremities
  13. Which of the following is correct regarding propofol?  





    A) Fospropofol is its pro-drug
  14. Which of the following is paired incorrectly:      



    C) Propofol / potentiate GABA-B receptors
  15. Which of the following is NOT a type of blockade of local anesthetics?




    C) Cerebral
  16. Which of the following statement is true regarding triptans? (select all that apply)
    A) good therapeutic agents for patients with high blood pressure
    B) safe for patients at risk for stroke or heart attacks
    C) good for patients with high blood pressure
    D) good for patients at risk for stroke or heart attacks
    E) ineffective for the symptoms of persistent pain
    • C) good for patients with high blood pressure
    • D) good for patients at risk for stroke or heart attacks
  17. Which of the following is not a pain-relieving medication in the treatment of migraine?





    B) Antidepressants
  18. Which of the following statements is true regarding sumatriptan? (select all that apply)              



    • D) B) It is a 5-HT agonist
    • C) It is a 5-HT1 agonist
  19. Which of the following is depolarizing muscle relaxant? 




    E) Succinylcholine
  20. Which of the following are amide local anesthetics? (select all that apply)    
    A) Procaine
    B) Procainamide
    C) Tetracaine
    D) Lidocaine
    E) Bupivacaine
    • D) Lidocaine
    • E) Bupivacaine
  21. Which of the following local anesthetics has a high risk of cardiac toxicity?  




    B) Bupivacaine
  22. Which of the following is a correct order of dose-dependent action of opioid?    



    A) Analgesia / nausea / constipation / sedation / respiration depression / miosis
  23. Which of the following chemical does not plays a role in nociceptive signal sensation/transmission?




    C) Epinephrine
  24. High dose of aspirin reduces the formation of prostaglandins by inhibiting:   




    A) Cyclooxygenase 2 (COX2)
  25. Activation of opioid µ receptors can inhibit pain sensation by increasing        




    E) Outward potassium current
  26. Activation of opioid µ receptors can inhibit pain sensation by decreasing      




    C) Inward calcium current
  27. Which one of the following statements regarding prostaglandins is/are true?



    C) They sensitize nerve endings to pain stimuli
  28. Which of the following agents has the least efficacy in treating acute tissue inflammation?  



    B) Acetaminophen
  29. All of the following are the therapeutic effects of aspirin EXCEPT:



    A) Reducing bleeding tendency
  30. Which of the following drugs inhibits cyclooxygenases irreversibly?     



    D) Aspirin (acetylsalicylic acid)
  31. Which of the following drugs shows reduced GI side effect, yet has elevated risks for myocardial infarction and stroke?



    A) Celecoxib
  32. Alcohol increases which of the following drug’s liver toxicity?



    C) Acetaminophen
  33. NAPQI (N-acetyl-p-benxoquinone imine) is a toxic metabolite of:



    A) Acetaminophen
  34. Induction of CYP enzymes 1A2, 2E1 and 3A4 may increase which of following drug’s hepatotoxicity?



    D) Acetaminophen
  35. Opioid receptors belong to: 




    B) G-protein coupled receptor family
  36. All of the following statements about opioid analgesics are true EXCEPT     



    C) They do not cause respiratory depression even when overdosed
  37. Which drug is an opioid antagonist and used for treating opioid addiction?   



    D) Naloxone
  38. Non-selective NSAIDs inhibit which of the following enzymes? (Select all that apply) 



    • B) Cyclooxygenase 1 (COX1)
    • C) Cyclooxygenase 2 (COX2)
  39. At anti-inflammatory dosage, aspirin inhibits which of the following enzyme(s)? (Select all that apply) 



    • B) Cyclooxygenase 1 (COX1)
    • C) Cyclooxygenase 2 (COX2)
  40. At analgesic dosage, aspirin inhibits which of the following enzyme(s)? (Select all that apply)



    • B) Cyclooxygenase 1 (COX1)
    • C) Cyclooxygenase 2 (COX2)
  41. At antipyretic dosage, aspirin inhibits which of the following enzyme(s)? (Select all that apply)



    • C) Cyclooxygenase 1 (COX1)
    • C) Cyclooxygenase 2 (COX2)
  42. At low dosage (such as baby aspirin), aspirin inhibits which of the following enzyme(s)?



    B) Cyclooxygenase 1 (COX1)
  43. Flurbiprophen is:   



    C) A non-selective COX inhibitor
  44. Which of the following statement is true regarding celecoxib? (Select all that apply)   



    • C) A) It selectively inhibits COX2 activity
    • B) It reversibly inhibits COX2 activity
  45. Which of the following is a correct rank order regarding the relative risks of GI complications of these NSAIDs (“< ” means less risk than)? 




    A) Aspirin < Naproxen < Indomethacin < Piroxicam
  46. Drug interaction between NSAIDs and thiazide diuretics is mainly related to which of the following molecules?



    C) Prostaglandins
  47. Reduction in which of the following mediator will cause hyperkalemia by NSAIDs and ACEIs? 




    D) Aldosterone
  48. Which of the following opioid receptor subtypes is the most important one that mediates the analgesic effect of morphine?        



    A) µ (mu)
  49. Which of the following is a mixed agonist-antagonist of opioid receptors?     




    A) Nalbuphine
  50. Which of the following is a most potent opioid agonist?   




    A) Fentanyl
  51. Which of the following is the least potent opioid agonist? 




    B) Propoxyphene
  52. Activation of which of the opioid receptors may produce dysphoric effect?  



    D) k (kappa)
  53. Which of the following is/are opioid antagonist(s)? (select all that apply)     



    • A) B) Naltrexone
    • C) Naloxone
Author
ebmalonzo
ID
320127
Card Set
Pain Wang
Description
IT 3 (MT 3): Pain Wang
Updated