EENT-Derm plus pharm

  1. nystatin (Mycostatin)
    • Therapeutic class: antifungal
    • Preg cat: C
    • MOA: Binds to membrane sterols in fungal cell causing leakage-kill son contact
    • Indications: Topical fungal infections or oral fungal infections. depending on infection route may differ.
    • Contraindications: hypersensitivity
    • Adverse: skin irritation
  2. amphotericin (Fungizone)
    • Therapeutic class: Antifungal
    • Preg: B 
    • MOA: Binds to membrane sterols in fungal cell causing leakage-kills on contact
    • Indications: effective against a wide range of fungi
    • Contraindications: hypersensitivity 
    • Adverse: N/V, fever, chills, headache, nephrotoxicity
    • Alerts: Infuse slowly IV, hold for elevated BUN or creatinine.
    • Interactions: Many
  3. permethrin (Elimite, Nix)
    scabicide, pediculicide
    • Therapeutic class: Antiparasitic
    • Preg: B
    • MOA: Affects the nervous system of parasite causing paralysis, they did in 24-48 hours because they're unable to feed.
    • Indications: scabies, parasites
    • Contraindications: Hypersensitivity 
    • Adverse: itching, burning, rash, redness, edema
    • Alert: Caution with asthma, lactating or inflamed skin. Wear gloves-for lice-medications should remain on on head for 10 mins. Itching may persist for up to 2-3 weeks. Avoid Face and groin
    • 1% for Lice
    • 5% for scabies
  4. mafenide acetate (Sulfamylon)
    • Therapeutic class: antibacterial
    • Preg: C
    • MOA: Bacteriostatic: Interferes with bacterial cell-wall synthesis and metabolism– Effective against gram negative organisms
    • Indications: topical water soluble antibacterial agent in 2nd and 3rd degree burns.
    • Contraindications: hypersensitivity
    • Adverse: metabolic acidosis, respiratory alkalosis, blistering, superinfections. Life threatening reactions-Bone marrow suppression, fatal hemolytic anemia. 
    • Alert: Assess electrolytes and acid-base balance-BUN/creatinine
  5. Accutane
    • Therapeutic class: Antiacne
    • Preg: X
    • MOA: decreases sebum production, causes apoptosis in sebaceous glands as well as others. 
    • Indications: decrease sebum production, severe acne with cysts.
    • Contraindications: Pregnancy, sunburns, eczema, children under 12, hepatic disease, leukopenia, neutropenia
    • Adverse: Bone pain–, Fever, –Headache,– Nausea–, Vomiting, –Rash–, Stomatitis, –Pruritus–, Sweating –Ocular disorders 25% of patients develop retinoic acid syndrome (–Fever, Weakness, Fatigue, Edema, Pulmonary involvement)
    • Alert: occuations with prolonged sun exposure.
  6. Retinoid (Avita, Retin-A)
    • Therapeutic class: antiacne
    • Preg: C
    • MOA: Carboxylic acid form of vitamin A-for skin turnover.
    • Indications: Acne
    • Contraindications: 
    • Adverse: Increased sensitivity to sunlight, –Redness–, Scaling erythema, –Crusting and peeling of skin
  7. pilocarpine (Isoptocarpine)
    • Therapeutic class: parasympathomimetic 
    • Preg: C
    • MOA: muscarinic receptor agonist in PNS-causing contraction of iris sphincter muscles allowing an increase of aqueous outflow
    • Indications: open and closed angle glaucoma
    • Contraindications: narrow-angle glaucoma, hypersensitivity, pupillary block glaucoma, uncontrolled asthma,
    • Adverse: Dyspnea–, Hypertension–, Tachycardia–, Retinal detachment–, Bronchospasm [long term use]
    • Antidote: Atropine
    • Alert: Apply pressure to lacrimal ducts in order to prevent systemic effects.
  8. mydriasis causes what to the eyes?
    Dilation of pupils-cycloplegics-used for eye exams. not use for patient with glaucoma due to potential for glaucoma attack.
  9. Myosis is what condition of the eye?
  10. what is timoptic used for?
    • Is a non selective beta 1 and beta 2 adrenergic receptor blocking agent which reduces vasodilation.  decreases cardiac output and also causes a decrease in aqueous humor and an increase in outflow. 
    • Decreasing production of aqueous-decreasing intraocular pressure. used for open angle glaucoma, ocular hypertension, migraines, HTN. 
    • adverse effects: Bronchoconstriction( caution with asthma patients), dysrhythmias, hypotension, burning
    • Alert: remain immobile for 5 minutes before driving.
  11. what is xalatan used for?
    • believed to reduce intraocular pressure by increasing the outflow of aqueous humor.
    • dilates trabecular meshwork.Used for ocular hypertension and open angle glaucoma.
  12. Glaucoma
    • increased Intraocular pressure.
    • if left untreated leads to optic nerve damage
  13. auralgan anesthetic
    is an otic solution containing antipyrine, benzocaine, and dehydrated glycerin.
  14. Ottis media
    • inflammation behind the tympanic membrane-with accumulation of fluids. viral or bacterial
    • 48-72 hours is watchful waiting for children 2 years and older due to most being viral.
    • Can cause conductive hearing loss later in life.
  15. Long term use of prednisone can lead to?
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EENT-Derm plus pharm
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