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Genetics - required/strongly recommended
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Abacavir
HLA-B*5701 positive
Hypersensitivity risk increased
Abacavir is contained in:
Ziagen
Epzicom (w/ lamivudine)
Trizivir (w/zidovudine)
Clopidegrel (Plavix)
CYP2C19 PM
Increased CV events
Requires conversion by CYP2C19 to active form
Carbamazepine (Tegretol)
HLA-B*1502 positive
TEN and SJS
Trastuzumab (Herceptin)
HER2/neu oncogene positive
CAN USE DRUG
Ado-trastuzumab emtansine (Kadcyla)
HER2/neu oncogene positive
CAN USE DRUG
Lapatinib (Tykerb)
HER2/neu oncogene positive
CAN USE DRUG
Pertuzumab (Perjeta)
HER2/neu oncogene positive
CAN USE DRUG
Cetuximab (Erbitux)
K-Ras positive
Not effective in COLON CANCER- DO NOT USE
EGFR positive
CAN USE DRUG in non-small cell lung cancer
Panitumumab (Vectibux)
K-Ras positive
Not effective in COLON CANCER- DO NOT USE
Erlotinib (Tarceva)
EGFR positive
CAN USE DRUG in non-small cell lung cancer
Afatinib (Gilotrif)
EGFR positive
CAN USE DRUG in non-small cell lung cancer
Imatinib (Gleevec)
CD117 (KIT, C-Kit) positive
CAN USE FOR gastrointestinal stromal tumors
BCR-ABL positive (Philadelphia chromosome)
CAN USE FOR chronic myelogenous leukemia (CML)
Maraviroc (Selzentry)
CCR5 positive
CAN use drug for HIV
CXCR4-tropic positive
DO NOT use for HIV
Dasatinib (Sprycel)
BCR-ABL positive (Philadelphia chromosome)
CAN USE FOR chronic myelogenous leukemia (CML)
Nilotinib (Tasigna)
BCR-ABL positive (Philadelphia chromosome)
CAN USE FOR chronic myelogenous leukemia (CML)
Bosutinib (Bosulif)
BCR-ABL positive (Philadelphia chromosome)
CAN USE FOR chronic myelogenous leukemia (CML)
Ponatinib (Iclusig)
BCR-ABL positive (Philadelphia chromosome)
CAN USE FOR chronic myelogenous leukemia (CML)
Rituximab (Rituxan)
B-Cell CD20 expression positive (main mechanism of action)
CAN USE drug
Ofatumumab (Arzerra)
B-Cell CD20 expression positive (main mechanism of action)
CAN USE drug
Simeprevir (Olysio)
NS3 Q80K positive
DO NOT USE - will not respond
Crizotinib (Xalkori)
Anaplastic Lymphoma kinase (ALK) positive
CAN USE DRUG
Ceritinib (Zykadia)
Anaplastic Lymphoma kinase (ALK) positive
CAN USE DRUG
Vemurafenib (Zelboraf)
BRAF V600E or V600K positive
CAN use drug for melanoma
Dabrafenib (Tafinlar)
BRAF V600E or V600K positive
CAN use drug for melanoma
Trametinib (Mekinist)
BRAF V600E or V600K positive
CAN use drug for melanoma
Azathioprine
Thiopurine methyltransferase (TPMT) positve for loss of function alelle
Increased risk of myelosupression
Do not use or start at very low dose
Mercaptopurine
Thiopurine methyltransferase (TPMT) positve for loss of function alelleIncreased risk of myelosupression Do not use or start at very low dose
Mercaptopurine
Thiopurine methyltransferase (TPMT) positve for loss of function alelle
Increased risk of myelosupression
Do not use or start at very low dose
Lenalidomide (Revlimid)
5q deletion positive
CAN USE DRUG
Increased hematologic toxicity, but better therapy response
Tositumomab
MS4A1 (CD-20 antigen) positive
CAN use
CD-20 is main MOA
Brentuximab vedotin (Adcetris)
TNFRSF8 (CD-30 antigen) positive
CAN USE drug
Main MOA
DEnileukin diftitox (Ontak)
IL2RA (CD-25 antigen) positive
Can use
Clopidegrel
Plavix
Carbamazepine
Tegretol
Trastuzumab
Herceptin
Ado-trastuzumab emtansine
Kadcyla
Lapatinib
Tykerb
Pertuzumab
Perjeta
Cetuximab
Erbitux
Panitumumab
Vectibux
Erlotinib
Tarceva
Afatinib
Gilotrif
Imatinib
Gleevec
Maraviroc
Selzentry
Dasatinib
Sprycel
Nilotinib
Tasigna
Bosutinib
Bosulif
Ponatinib
Iclusig
Rituximab
Rituxan
Ofatumumab
Arzerra
Simeprevir
Olysio
Crizotinib
Xalkori
Ceritinib
Zykadia
Vemurafenib
Zelboraf
Dabrafenib
Tafinlar
Trametinib
Mekinist
Lenalidomide
Revlimid
Brentuximab vedotin
Adcetris
Denileukin diftitox
Ontak
Author
kyleannkelsey
ID
318946
Card Set
Genetics - required/strongly recommended
Description
Genetics
Updated
2016-04-14T19:28:32Z
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