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Which membrane proteins connect neighboring cells and account for the immunological properties of cell?
Peripheral
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The cell membrane is composed of a lipid bilayer are the heads polar or nonpolar? The tails?
Polar heads, nonpolar tails
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What can pass through a cell membrane?
small molecules, water
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What compound is necessary for active transport to take place?
ATP
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Which type of diffusion is saturable?
Facilitated
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Fick's law of diffusion depends on what factors?
concentration diff., area, diffusion coeff., membrane thickness
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Facilitated diffusion usually applies to polar or nonpolar substance?
Polar
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What is a carrier?
An integral membrane protein, allows binding of substrate which it then passes through membrane into cell
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Why is facilitated diffusion saturable?
depends on # carrier proteins present, once depleted the substrate must wait for more
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K+/Na+ which has two gates? which has one?
Na+=2, K+=1
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In channels with 1 gate a _____ stimulus opens the gate, opening the gate is depolarization/repolarization?
Electrical, depolarization
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Resting position for Na+ channel is ______ gate open and ____ gate closed?
Inactivation, activation
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In Na+ channels the _____ gate is electrically controlled, ______ gate is time controlled?
Activation, Inactivation
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The charge inside a cell is_____ the charge outside is ____?
Inside -, Outside+
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Electrically gated channels are found in what two cell types?
Nerve, Muscle
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The driving force for movement of particles through channels is the _____?
electrical-chemical gradient
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Is the transport through membrane channels saturable?
yes
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The Na+/K+ pump is an example of ______transport?
Primary Active
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The Na+/K+ pump moves ______Na+ out and _____K+ in?
3Na+ out, 2K+in
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In _____ transport the carriers and substrate can move in the same or opposite directions?
secondary active
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In ______ transport the carriers and substrate are moved in opposite directions it is called _____?
Antiport
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When the carrier and substrate move in the same direction it is called______?
Symport
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Which part of secondary active transport requires no energy?
First
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What is the source of energy of the Na/K pumps?
1ATP
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_______ splits ATP into ADP+phosphate for energy?
ATPase
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______ ion transport has no effect on the membrane potential while ____ changes the membrane potential?
Electroneutral, electrogenic
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Which transport mechanism describes the volume flow of water carrying dissolved substances?
Bulk flow
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______ is when cells take in large particles by surrounding them with projections of its membrane called_____?
Phagocytosis, pseudopods
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_____ is where tiny droplets of extracellular fluid are surrounded by pseudopods and incorporated in vesicles?
Pinocytosis
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____ is where incorporated vesicles fuse with the cell membranes and release their contents to ECF?
exocytosis
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Which transport mechanism has the ability to change membrane potential?
electrogenic symport/antiport
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The resting membrane potential is?
-70mV
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What is peak membrane potential at depolarization?
~+30mV
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The ______ refractory period is the time during an action potential when no amount of stimulus can initiate another AP?
relative
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The _____ refractory period is time during which a strong stimulus can initiate another action potential?
relative
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Does diffusion of Cl- out of cell increase or decrease membrane potential?
decrease
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Fast/slow Na+ channels cause what?
fast, depolarization
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Fast/slow K+ channels cause what?
slow, repolarization
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Which ions/molecules are found in higher concentrations in extracellular fluid(ECF)?
Na+, Cl-, Ca++, bicarbonate
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Which ions/molecules are found in higher concentrations in the intracellular fluid(ICF)?
K+, inorganic phosphate, inorganic sulfates, organic acids/proteins
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How can the membrane potential generated by one univalent ion be calculated?
Nernst equation
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Explain difference in Nerst and GHK equations?
Nernst=calculation for 1ion, GHK=calculation for >1ion
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What would be effect on membrane potential if ATP synthesis by mitochondria stopped?
ATP couldn't open channels for Na, K potential would slowly become 0
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Ca++ ions carry 2+ charges and are higher in concentration in ECF. Why does this contribute so little to membrane potential?
Very low compared to Na+, pretty much no effect
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Na+/K+ causes depolarization while Na+/K+ causes repolarization?
Na+ depolarize, K+ repolarize
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What is the normal duration on an action potential?
~3-5 milliseconds
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_____ is when depolarization reaches a certain value, generating an action potential?
Threshold
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_____ is the electrical discharge across a cell membrane?
action potential
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______ occurs because K+ channels close slowly leading to K+ slowly diffusing out of cell?
hyperpolarization
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____ is the principle stating that any depolarization of the cell either has no effect or results in an action potential?
all or none
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_______ propagate action potentials afferently while ______ propagate action potentials efferently?
dendrites, axons
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_______neurons carry info toward the brain and spinal cord?
sensory or afferent
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_____ connects two neurons and transmits info
interneurons
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____ neurons carry info out of brain or spinal cord to effect cells?
motor or efferent
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______ surrounds the axon and speeds up conduction?
schwann cells
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____ are gaps in myelin sheaths?
nodes of ranier
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______ conduction occurs quickly on axons w/schwann cells?
saltatory
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_____ conduction occurs on non-myelinated axons?
continuous conduction
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_____ and _____ determine rate of conduction?
insulation and size(diameter) or type and diameter
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_____ fibers are the fastest?
A, then B, then C slowest
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_____ fibers are sympathetic, postganglionic?
C
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_____ fibers are sympathetic preganglionic?
B
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______ synapses are found in cardiac/smooth muscle?
Electrical
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_____ synapses are found in skeletal muscle?
chemical
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______ synapses require a neurotransmitter and Ca++?
chemical
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In a ______ synapse action potentials open the Na++ channels?
excitatory
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In a _____ synapse action potential open Cl-, K+ channels?
inhibitory
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An EPSP/IPSP is caused by a flow of positively charged ions into postsyaptic cell.
EPSP
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_____summation is more than one synapse depolarizing simultaneously?
Spatial
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______ summation is a series of action potentials from one synapse depolarizing repeatedly?
temporal
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The _____ consists of brain and spinal cord?
CNS
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The _____ maintains homeostasis in the body?
ANS
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The PNS uses only _____ as it's neurotransmitter?
ACh
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Both _____ and ______ mimic the affect of ACh and act on its receptors?
Nicotinic and muscarinic
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_______ blocks muscarinic receptor?
Atropine
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Atropine causes?
tachycardia
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____ receptors are on postganglionic neurons?
muscarinic
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_____ prevents the depolarization of the postsynaptic membrane of the motor end plate leading to muscle paralysis
curarine
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_____ synapses use ACh as a neurotransmitter and ________ synapses us E or NE
cholinergic, adrenergic
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The sympathetic division uses___ as a pre-ganglionic transmitter and usually ____ as a post?
ACh, NE
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_____ receptors are classified into Alpha and Beta
Adrenergic
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____binds better to alpha receptors and ____ binds better to beta receptors?
NE, E
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_____ agents mimic the effects of parasympathetic stimulation, 2 examples?
Parasympathomimetic, muscarine/nicotine
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_____ agents reduce or block the effects of parasympathetic stimulation? example?
Parasympatholytic, atropine
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_____ causes constriction of blood vessels and bronchi, decrease lipolysic and inhibits insulin secretion?
NE
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What is the term for a drug having a diminished effect after repeated application?
tachyphylaxis
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____ are used to treat peripheral vasospasm?
alpha blockers
-
List selective beta and nonselective beta blockers?
B1,B2, or B3 non= B1, B2, and B3
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____ are used to treat prophylaxis of angina pectoris and arrthmias
B1 blockers
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More than 2 neurons are involved in a ____ reflex.
polysynaptic
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____ reflexes are the simplest, consisting of only 2 neurons
monosynaptic
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Proprioceptive reflexes are also called?
idioreflexes
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Stretch receptors in the muscle are called _____ and _____ in the tendons?
neuromuscular, golgi's corpuscles
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A____is the neutral pathway that mediates reflex action?
reflex arc
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The ____ reflex causes contraction of extensor muscles in the limb opposite a painful stimulus
crossed extensor reflex
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If a polysynaptic reflex recruits additional areas it is called?
integrated response
-
the ___ is the smallest functional subunit for skeletal muscle contraction?
sarcomere
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____ separate the sarcomeres?
Z plates
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The ____ is the region where actin filaments are on both sides of z-plate?
I-bands
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The ____ is the region in which actin and myosin filaments overlap?
A-band
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the ___ consists of only myosin filaments
H-zone
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one filament sliding shortens a sarcomere by ____% and _____ is maximum it can be shortened
1,50
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Binding of ____ to troponin terminates the inhibitiory effect of tropomuosin, leading to myosin/actin binding?
Ca++
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____ splits ATP into ADP and phospate, ____ is required for this?
ATPase, Mg++
-
Dissociation of the ____ tips the head from 90-50 degrees? 50-45?
Phosphate, ADP
-
Rigor mortis occurs when ____ is no longer produced?
ATP
-
Binding of _____ lifts the head off the actin?
ATP
-
The ____ is the intracellular reservoir for Ca ++
L-system, aka sarcoplasmic reticulum
-
Cardiac AP's are much _____ than nerve and muscle AP's?
longer
-
____ is responsible for the duration of cardiac AP's
Ca++
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Ca++ deficiency causes the muscles to remain in state of _____?
relaxation
-
______ muscle depends on extracellular Ca++ _____ muscle doesn't?
Cardiac, skeletal
-
What causes Ca++ release from L-system?
depolarization and Ca++ influx from ECF
-
What transport mechanism is responsible for transporting Ca++ back into the sarcoplasmic reticulum after contraction ?
active transport
-
The synapse connecting motor neuron and muscle fiber is called ______?
motor end plate
-
A _____ consists of one neuron and all skeletal muscle cells innervated by it?
motor unit
-
The motor unit is the functional unit of ____muscle?
Skeletal
-
If ____ muscle fibers are innervated by one motor unit you get a finer control.
less
-
____ twitch motor units predominate in white muscle?
fast
-
The arrangement of muscle cells in the heart is called?
functional syncytium
-
____ connect the ends of neighboring muscle fibers?
intercalated discs (gap junctions)
-
_____ muscles do not depend on the CNS for stim?
smooth
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Max sustained contraction of skeletal muscle is called?
tetanus
-
How is tetanus attained in cardiac muscle?
not possible
-
____ muscle contains no sarcomeres.
smooth
-
_____ contraction is where the tension on the muscle changes but the muscle length stays the same?
Isometric
-
_____ contraction is where both length and tension change?
auxotonic
-
____ muscle has the slowest rate of AP's
smooth
-
____ tension is determined by the number of actin/myosin cross-bridges, when ____ tension is determined by elastic muscle components?
active ,passive
-
____ is the prolonged shortening of the muscle caused by either a sustained local depolarization or by pharmacologically induced Ca++ release?
contracture
-
The force of a muscle contraction is determined by which 2 factors?
#motor units, frequency of AP's
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