-
bevacizumab
- monoclonal antibody against vascular endothelial growth factor, inhibiting angiogenesis. Solid tumors (esp colorectal, renal cell carcinoma)
- hemorrhage, blood clots, impaired wound healing
-
ranibizumab
- monoclonal antibody against vascular endothelial growth factor, inhibiting angiogenesis. Neovascualr age-related macular degeneration
- hemorrhage, blood clots, impaired wound healing
-
erlotinib
- epidermal growth factor recptor tyrosine kinase inhibitor. Non-small cell lung cancer
- Rash
- the erl of EnGland and FRance wanted to get fit, so he pandered to the cetizens (erlotinib, EGFR, gefitinib, panitumumab, cetuximab)
-
cetuximab
- monoclonal antibody against epidermal growth factor recptor. Stage IV colorectal cancer (wild type KRAS only!), head and neck cancer
- Rash, hepatotoxic, diarrhea
- the erl of EnGland and FRance wanted to get fit, so he pandered to the cetizens (erlotinib, EGFR, gefitinib, panitumumab, cetuximab)
-
imatinib
- tyrosine kinase inhibitor of BCR-ABL and c-kit. CML, GI stromal tumors
- fluid retention
-
rituximab
- monoclonal antibody against CD-20. Non-Hodgkin lymphoma, CLL, immune thrombocytopenic purpura (ITP), RA
- increased risk of progressive multifocal leukoencephalopathy (JC virus)
- ri2Ximab (2X=20, CD20, rituximab)
-
trastuzumab
- aka herceptin
- monoclonal antibody against human epidermal growth factor receptor 2 HER-2 (c-erbB2) (tyrosine kinase). HER-2 postivie breast and gastric cancer
- her trashy bra makes her 2 boobs look new (trastuzumab, breast cancer, HER-2/neu)
- heartceptin (cardiotoxicity, trastuzumab[herceptin])
-
vemurafenib
- small molecule inhibitor of BRAF oncogene. V600E-mutated BRAF metastatic melanoma
- VEmuBRAFinhib (V600E-mutated BRAF inhibitor)
-
cyclosporine
- binds cyclophilin to inhibit calcineurin, reducing nuclear factor of activated T cells (NFAT), preventing IL-2 expression and inhibiting T cell activation. Transplant rejection prophylaxis, psoriasis, RA
- nephrotoxicity, HTN, hyperlipidemia, neurotoxicity, gingival hyperplasia, hirsutism
- bicyclosporine (IL-2, cyclosporine)
-
tacrolimus
- aka FK506
- binds FK506 binding protein (FKBP) to inhibit calcineurin, reducing nuclear factor of activated T cells (NFAT), preventing IL-2 expression. Transplant rejection prophylaxis
- I'll have a taco with lime and a taco without lime (IL-2 [one of each taco], tacrolimus, FK506[you could work "fucking" 5-6 times into that sentence])
-
sirolimus
- aka rapamycin
- binds FK506 binding protein (FKBP) to inhibit mTOR, reducing response to IL-2, inhibiting B cell differentiation and T cell activation
- pancytopenia, insulin resistance, hyperlipidemia, not nephrotoxic(tacrolimus and cyclosporine are)
- kidney sirvives (not nephrotoxic, sirolimus)
- sir olimus responds to maiden B and maiden T in the tower (sirolimus, response to IL-2[two maidens], rapamycin[maidens], B cells, T cells, mTOR[maiden tower])
-
daclizumab
- monoclonal antibody against IL-2 receptors. Kidney transplant
- edema, hypertension, tremor
- Harry Potter and the Chamber of daiquiris (basiliximab, daclizumab, IL-2R[second book])
-
basiliximab
- monoclonal antibody against IL-2 receptors. Kidney transplant
- edema, hypertension, tremor
- Harry Potter and the Chamber of daiquiris (basiliximab, daclizumab, IL-2R[second book])
-
mycophenolate mofetil
- reversible inhibtion of IMP dehydrogenase to prevent purine nucleotide formation, reducing B and T cell synthesis. Transplant rejection, lupus nephritis
- GI upset, pancytopenia (CMV infection), hypertension, hyperglycemia, less nephro/neurotoxic
- Stephen Moffat has a pure hatred of imps (mycophenolate mofetil, purine, IMP dehydrogenase)
-
aldesleukin
- recombinant IL-2. Renal cell carcinoma, metastatic melanoma
- ILdes2kin (IL-2, aldesleukin)
-
epoetin alfa
recombinant erythropoietin. Anemias, especially with renal failure
-
filgrastim
- recombinant granulocyte colony stimulating factor. Bone marrow recovery
- fill up the grans (filgramstim, granulocyte colony stimulating factor
-
sargramostim
- recombinant granolycte macrophage colony stimulating factor. Bone marrow recovery
- sorta gran o stimulator (sargramostim, granolycte macrophage colony stimulating factor)
-
romiplostim
recombinant thrombopoietin receptor agonist. Thrombocytopenia
-
eltrombopag
recombinant thrombopoietin receptor agonist. Thrombocytopenia
-
Oprelvekin
- recombinant IL-11. Thrombocytopenia
- Oprah livin one by one day at a time (oprelvekin, IL-11)
-
alemtuzumab
- monoclonal antibody against CD52. CLL, MS
- almenactuzumab (CD 52 [weeks in a year for almenac], alemtuzumab)
-
eculizumab
- monoclonal antibody of complement protein C5. Paroxysmal nocturnal hemoglobinuria
- your E Coli zoo copmlements my pig pen (C5 [E=5], eculizumab, complement, PNH[pig])
-
natalizumab
- monoclonal antibody of alpha4 integrin, reducing WBC adhesion. Multiple sclerosis, Chron disease
- increased risk of progressive multifocal leukoencephalopathy in patients with JC virus
- natali is lacking for integrity and her brain is filled with junk (natalizumab, alpha4 (for), integrin, leukoencephalopathy, JC virus)
-
denosumab
- monoclonal antibody targetting RNAKL to inhibit osteoclast maturaiton. Osteoporosis
- dem bones sumab (denosumab, osteoporosis)
-
bethanechol
- direct agonist of ACh receptors. Posteroperative ileus, neurogenic ileus, urinary retention
- bathroomanechol (ileus, urinary retention, bethanechol)
-
edrophonium
- anticholinesterase used to increase ACh levels. Myasthenia gravis diagnosis
- exacerbation of COPD, asthma, peptic ulcers
-
neostigmine
- anticholinesterase used to increase ACh levels without CNS penetration. Postoperative ileus, neurogenic ileus, urinary retention, myasthenia gravis, postoperative reversal of blockade
- exacerbation of COPD, asthma, peptic ulcers
-
physostigmine
- anticholinesterase used to increase ACh levels with CNS penetration. Anitcholinergic toxicity (tertiary amines can cross BBB)
- physiostigmine (return to physio, physostigmine)
- exacerbation of COPD, asthma, peptic ulcers
-
pyridostigmine
- anticholinesterase used to increase ACh levels without CNS penetration, long-acting. Myasthenia gravis (long-acting)
- exacerbation of COPD, asthma, peptic ulcers
-
atropine
muscarinic antagonist. Bradycardia treatment, eye dilation
-
homatropine
muscarinic antagonist. Bradycardia treatment, eye dilation
-
tropicamide
muscarinic antagonist. Bradycardia treatment, eye dilation
-
benztropine
- muscarinic antagonist, CNS acting. Parkinson disease, acute dystonia
- park my benz (parkinson, benztropine)
-
glycopyrrolate
muscarinic antagonist, GI and respiratory. Preoperative airway secretion reduction, peptic ulcers, drooling
-
hyoscyamine
muscarinic antagonist, GI acting. Irritable bowel syndrome
-
dicyclomine
muscarinic antagonist, GI acting. Irritable bowel syndrome
-
oxybutynin
muscarinic antagonist, GU acting. Overactive bladder (urgency and bladder spasm reduction)
-
solifenacin
muscarinic antagonist, GU acting. Overactive bladder (urgency and bladder spasm reduction)
-
tolterodine
muscarinic antagonist, GU acting. Overactive bladder (urgency and bladder spasm reduction)
-
scopolamine
muscarinic antagonist, CNS acting. Motion sickness
-
dobutamine
beta 1 agonist more than beta 2 and alpha, increasing hear contractility with mild heart rate increase. Heart failure, cardiac stress testing
-
dopamine
agonist at dopamine receptors 1 and 2 more than beta and alpha receptors. Lower doses have more beta effects (ionotrophic and chronotrophic), used for unstable bradycardia, HF. Higher doses have more alpha effects, shock
-
isoproterenol
- equal agonist at beta 1 and beta 2. Electrophysiologic evaluation of tachyarrhythmia
- worsened ischemia
-
midodrine
- agonist at alpha 1. Autonomic insufficiency, postural hypotension
- worsened supine hypertension
-
norepinephrine
agonst at alpha 1 more than alpha 2 more than beta 1. Hypotension, septic shock
-
clonidine
- alpha 2 agonist, reducing sympathetic output. Hypertensive urgency, ADHD, Tourette syndrome
- CNS depression, bradycardia, hypotension, respiratory depression, misosis
-
guanfacine
- alpha 2 agonist, reducing sympathetic output. Hypertensive urgency, ADHD, Tourette syndrome
- CNS depression, bradycardia, hypotension, respiratory depression, misosis
-
alpha methyldopa
- alpha 2 agonist, reducing sympathetic output. Hypertension in pregnancy
- direct coombs hemolysis, induced lupus
-
phenoxybenzamine
- irreversible alpha 1 and alpha 2 (equal) blockade. Used preoperatively in pheochromocytoma to prevent hypertensive crisis
- orthostatic hypotension, reflex tachycardia
- ephen bloxy benzamine (even alpha, block)
-
phentolamine
- reversible alpha 1 and alpha 2 (equal) blockade. Used in hypertensive crisis from tyramine and MAOIs
- orthostatic hypotension, reflext tachycardia
- ephen toll amine (even, alpha, block)
-
fomepizole
inhibitor of alcohol dehydrogenase, ethanol/methanol not broken down to acetaldehyde/formaldehyde. Ethanol/methanol poisoning
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