The Pharm of Old McDonald 10

• monoclonal antibody against vascular endothelial growth factor, inhibiting angiogenesis. Solid tumors (esp colorectal, renal cell carcinoma)
• hemorrhage, blood clots, impaired wound healing

• monoclonal antibody against vascular endothelial growth factor, inhibiting angiogenesis. Neovascualr age-related macular degeneration
• hemorrhage, blood clots, impaired wound healing

• epidermal growth factor recptor tyrosine kinase inhibitor. Non-small cell lung cancer
• Rash
• the erl of EnGland and FRance wanted to get fit, so he pandered to the cetizens (erlotinib, EGFR, gefitinib, panitumumab, cetuximab)

• monoclonal antibody against epidermal growth factor recptor. Stage IV colorectal cancer (wild type KRAS only!), head and neck cancer
• Rash, hepatotoxic, diarrhea
• the erl of EnGland and FRance wanted to get fit, so he pandered to the cetizens (erlotinib, EGFR, gefitinib, panitumumab, cetuximab)

• tyrosine kinase inhibitor of BCR-ABL and c-kit. CML, GI stromal tumors
• fluid retention

• monoclonal antibody against CD-20. Non-Hodgkin lymphoma, CLL, immune thrombocytopenic purpura (ITP), RA
• increased risk of progressive multifocal leukoencephalopathy (JC virus)
• ri2Ximab (2X=20, CD20, rituximab)

• aka herceptin
• monoclonal antibody against human epidermal growth factor receptor 2 HER-2 (c-erbB2) (tyrosine kinase). HER-2 postivie breast and gastric cancer
• her trashy bra makes her 2 boobs look new (trastuzumab, breast cancer, HER-2/neu)
• heartceptin (cardiotoxicity, trastuzumab[herceptin])

• small molecule inhibitor of BRAF oncogene. V600E-mutated BRAF metastatic melanoma
• VEmuBRAFinhib (V600E-mutated BRAF inhibitor)

• binds cyclophilin to inhibit calcineurin, reducing nuclear factor of activated T cells (NFAT), preventing IL-2 expression and inhibiting T cell activation. Transplant rejection prophylaxis, psoriasis, RA
• nephrotoxicity, HTN, hyperlipidemia, neurotoxicity, gingival hyperplasia, hirsutism
• bicyclosporine (IL-2, cyclosporine)

• aka FK506
• binds FK506 binding protein (FKBP) to inhibit calcineurin, reducing nuclear factor of activated T cells (NFAT), preventing IL-2 expression. Transplant rejection prophylaxis
• I'll have a taco with lime and a taco without lime (IL-2 [one of each taco], tacrolimus, FK506[you could work "fucking" 5-6 times into that sentence])

• aka rapamycin
• binds FK506 binding protein (FKBP) to inhibit mTOR, reducing response to IL-2, inhibiting B cell differentiation and T cell activation
• pancytopenia, insulin resistance, hyperlipidemia, not nephrotoxic(tacrolimus and cyclosporine are)
• kidney sirvives (not nephrotoxic, sirolimus)
• sir olimus responds to maiden B and maiden T in the tower (sirolimus, response to IL-2[two maidens], rapamycin[maidens], B cells, T cells, mTOR[maiden tower])

• monoclonal antibody against IL-2 receptors. Kidney transplant
• edema, hypertension, tremor
• Harry Potter and the Chamber of daiquiris (basiliximab, daclizumab, IL-2R[second book])

• monoclonal antibody against IL-2 receptors. Kidney transplant
• edema, hypertension, tremor
• Harry Potter and the Chamber of daiquiris (basiliximab, daclizumab, IL-2R[second book])

• reversible inhibtion of IMP dehydrogenase to prevent purine nucleotide formation, reducing B and T cell synthesis. Transplant rejection, lupus nephritis
• GI upset, pancytopenia (CMV infection), hypertension, hyperglycemia, less nephro/neurotoxic
• Stephen Moffat has a pure hatred of imps (mycophenolate mofetil, purine, IMP dehydrogenase)

• recombinant IL-2. Renal cell carcinoma, metastatic melanoma
• ILdes2kin (IL-2, aldesleukin)

recombinant erythropoietin. Anemias, especially with renal failure

• recombinant granulocyte colony stimulating factor. Bone marrow recovery
• fill up the grans (filgramstim, granulocyte colony stimulating factor

• recombinant granolycte macrophage colony stimulating factor. Bone marrow recovery
• sorta gran o stimulator (sargramostim, granolycte macrophage colony stimulating factor)

recombinant thrombopoietin receptor agonist. Thrombocytopenia

recombinant thrombopoietin receptor agonist. Thrombocytopenia

• recombinant IL-11. Thrombocytopenia
• Oprah livin one by one day at a time (oprelvekin, IL-11)

• monoclonal antibody against CD52. CLL, MS
• almenactuzumab (CD 52 [weeks in a year for almenac], alemtuzumab)

• monoclonal antibody of complement protein C5. Paroxysmal nocturnal hemoglobinuria
• your E Coli zoo copmlements my pig pen (C5 [E=5], eculizumab, complement, PNH[pig])

• monoclonal antibody of alpha4 integrin, reducing WBC adhesion. Multiple sclerosis, Chron disease
• increased risk of progressive multifocal leukoencephalopathy in patients with JC virus
• natali is lacking for integrity and her brain is filled with junk (natalizumab, alpha4 (for), integrin, leukoencephalopathy, JC virus)

• monoclonal antibody targetting RNAKL to inhibit osteoclast maturaiton. Osteoporosis
• dem bones sumab (denosumab, osteoporosis)

• direct agonist of ACh receptors. Posteroperative ileus, neurogenic ileus, urinary retention
• bathroomanechol (ileus, urinary retention, bethanechol)

• anticholinesterase used to increase ACh levels. Myasthenia gravis diagnosis
• exacerbation of COPD, asthma, peptic ulcers

• anticholinesterase used to increase ACh levels without CNS penetration. Postoperative ileus, neurogenic ileus, urinary retention, myasthenia gravis, postoperative reversal of blockade
• exacerbation of COPD, asthma, peptic ulcers

• anticholinesterase used to increase ACh levels with CNS penetration. Anitcholinergic toxicity (tertiary amines can cross BBB)
• physiostigmine (return to physio, physostigmine)
• exacerbation of COPD, asthma, peptic ulcers

• anticholinesterase used to increase ACh levels without CNS penetration, long-acting. Myasthenia gravis (long-acting)
• exacerbation of COPD, asthma, peptic ulcers

muscarinic antagonist. Bradycardia treatment, eye dilation

muscarinic antagonist. Bradycardia treatment, eye dilation

muscarinic antagonist. Bradycardia treatment, eye dilation

• muscarinic antagonist, CNS acting. Parkinson disease, acute dystonia
• park my benz (parkinson, benztropine)

muscarinic antagonist, GI and respiratory. Preoperative airway secretion reduction, peptic ulcers, drooling

muscarinic antagonist, GI acting. Irritable bowel syndrome

muscarinic antagonist, GI acting. Irritable bowel syndrome

muscarinic antagonist, GU acting. Overactive bladder (urgency and bladder spasm reduction)

muscarinic antagonist, GU acting. Overactive bladder (urgency and bladder spasm reduction)

muscarinic antagonist, GU acting. Overactive bladder (urgency and bladder spasm reduction)

muscarinic antagonist, CNS acting. Motion sickness

beta 1 agonist more than beta 2 and alpha, increasing hear contractility with mild heart rate increase. Heart failure, cardiac stress testing

agonist at dopamine receptors 1 and 2 more than beta and alpha receptors. Lower doses have more beta effects (ionotrophic and chronotrophic), used for unstable bradycardia, HF. Higher doses have more alpha effects, shock

• equal agonist at beta 1 and beta 2. Electrophysiologic evaluation of tachyarrhythmia
• worsened ischemia

• agonist at alpha 1. Autonomic insufficiency, postural hypotension
• worsened supine hypertension

agonst at alpha 1 more than alpha 2 more than beta 1. Hypotension, septic shock

• alpha 2 agonist, reducing sympathetic output. Hypertensive urgency, ADHD, Tourette syndrome
• CNS depression, bradycardia, hypotension, respiratory depression, misosis

• alpha 2 agonist, reducing sympathetic output. Hypertensive urgency, ADHD, Tourette syndrome
• CNS depression, bradycardia, hypotension, respiratory depression, misosis

• alpha 2 agonist, reducing sympathetic output. Hypertension in pregnancy
• direct coombs hemolysis, induced lupus

• irreversible alpha 1 and alpha 2 (equal) blockade. Used preoperatively in pheochromocytoma to prevent hypertensive crisis
• orthostatic hypotension, reflex tachycardia
• ephen bloxy benzamine (even alpha, block)

• reversible alpha 1 and alpha 2 (equal) blockade. Used in hypertensive crisis from tyramine and MAOIs
• orthostatic hypotension, reflext tachycardia
• ephen toll amine (even, alpha, block)

inhibitor of alcohol dehydrogenase, ethanol/methanol not broken down to acetaldehyde/formaldehyde. Ethanol/methanol poisoning